Responsivity of the Striatal Dopamine System to Methylphenidate—A Within-Subject I-123-β-CIT-SPECT Study in Male Children and Adolescents With Attention-Deficit/Hyperactivity Disorder

Bibliographic Data

ID15529392
AuthorsHans-Christoph Aster (University of Würzburg, corresponding author), Marcel Romanos (0000-0001-7628-8299, University of Würzburg), Susanne Walitza (0000-0002-8161-8683, University of Zurich), Manfred Gerlach (University of Würzburg), Andreas Mühlberger (0000-0002-8352-0946, University of Regensburg), Albert Rizzo (0000-0003-2647-7731, University of Southern California), Marta Andreatta (0000-0002-1217-8266, Erasmus University Rotterdam), Natalie Hasenauer (University of Würzburg), Philipp E Hartrampf (0000-0001-5622-9849, University of Würzburg), Kai Nerlich (University of Würzburg), Christoph Reiners (0000-0001-8093-8725, University of Würzburg), R Lorenz (0000-0002-3661-9580, University of Würzburg), Andreas K Buck (0000-0002-6447-0613, University of Würzburg), Lorenz Deserno (0000-0001-7392-5280, University of Würzburg, corresponding author)
Year2022
Volume13
Pages804730-804730
Publication date2022-04-14
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2022.804730
PMID35492708
OpenAlexW4224107022
LanguageEN
References cited57

Our findings corroborate previous reports from mainly adult samples that MPH changes striatal DAT BP availability and suggest higher off-MPH DAT BP, likely reflecting low baseline DA levels, as a marker of symptom severity

Dopamine · Dopamine transporter · Methylphenidate · Psychiatry · Spect imaging · Stimulant · Striatum · Ventral striatum · Attention Deficit Hyperactivity Disorder · Bipolar Disorder and Treatment · Clinical Psychology · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology

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