Functional and Structural Alterations in the Cingulate Motor Area Relate to Decreased Fronto-Striatal Coupling in Major Depressive Disorder with Psychomotor Disturbances

Bibliographic Data

ID15529489
AuthorsBenny Liberg (Karolinska Institutet, corresponding author), Paul Klauser (0000-0003-0284-4947, The University of Melbourne), Ian H Harding (0000-0002-6843-9592, Monash University), Mats Adler (0000-0002-5905-0171, Karolinska Institutet), Christoffer Rahm (0000-0002-8934-5130, The University of Melbourne), Johan Lundberg (0000-0002-7905-1825, Karolinska Institutet), Thomas Masterman (0000-0001-9894-1877, Karolinska Institutet), Caroline Wachtler (0000-0002-1317-7732, The University of Melbourne), Tomas Jonsson (0000-0002-7520-7650, Karolinska Institutet), Maria Kristoffersen Wiberg (0000-0001-6577-8217, Karolinska Institutet), Maria Kristoffersen-Wiberg, Christos Pantelis (0000-0002-9565-0238, The University of Melbourne), Björn Wahlund, Björn Wahlund (Swedish University of Agricultural Sciences)
Year2014
Volume5
Pages176-176
Publication date2014-12-04
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2014.00176
PMID25538633
PMCIDPMC4255491
OpenAlexW1999352370
LanguageEN
Citations received1
References cited82

Psychomotor disturbances are a classic feature of major depressive disorders. These can manifest as lack of facial expressions and decreased speech production, reduced body posture and mobility, and slowed voluntary movement. The neural correlates of psychomotor disturbances in depression are poorly understood but it has been suggested that outputs from the cingulate motor area (CMA) to striatal motor regions, including the putamen, could be involved. We used functional and structural magnetic resonance imaging to conduct a region-of-interest analysis to test the hypotheses that neural activation patterns related to motor production and gray matter volumes in the CMA would be different between depressed subjects displaying psychomotor disturbances (n = 13) and matched healthy controls (n = 13). In addition, we conducted a psychophysiological interaction analysis to assess the functional coupling related to self-paced finger-tapping between the caudal CMA and the posterior putamen in patients compared to controls. We found a cluster of increased neural activation, adjacent to a cluster of decreased gray matter volume in the caudal CMA in patients compared to controls. The functional coupling between the left caudal CMA and the left putamen during finger-tapping task performance was additionally decreased in patients compared to controls. In addition, the strength of the functional coupling between the left caudal CMA and the left putamen was negatively correlated with the severity of psychomotor disturbances in the patient group. In conclusion, we found converging evidence for involvement of the caudal CMA and putamen in the generation of psychomotor disturbances in depression

Audiology · Cognition · Finger tapping · Functional magnetic resonance imaging · Psychomotor learning · Putamen · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Transcranial Magnetic Stimulation Studies

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