Altered cortical-striatal circuits connectivity is associated with psychotic symptoms in patients with first-episode, drug-naïve early-onset schizophrenia

Bibliographic Data

ID15529805
AuthorsLu Wang (0000-0002-9250-3988, The Affiliated Yongchuan Hospital of Chongqing Medical University), Ruishan Liu (Mianyang Third People's Hospital), Juan Liao (0000-0001-7314-373X, Mianyang Third People's Hospital), Fan Li (0000-0002-7481-0394), Li Fan (0000-0003-1780-6919, Mianyang Third People's Hospital), Lihua Zhuo (0009-0005-5674-0854), Lihua XieRenying Zhuo (Mianyang Third People's Hospital, corresponding author), Hongwei Li (0000-0001-5682-9780, Mianyang Third People's Hospital, corresponding author)
Year2026
Volume16
Pages1695904-1695904
Publication date2026-01-05
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2025.1695904
PMID41561987
OpenAlexW7118179477
LanguageEN
References cited81

EOS not only showed aberrant FC in cortico-striato-cerebellar circuits, but also exhibited disrupted causal connectivity in striatal-amygdala circuits and within prefrontal cortex. Importantly, hyperconnectivity within the cortical-striatal circuits may represent a key neural mechanism underlying the psychotic symptoms of EOS

Biological neural network · Functional connectivity · Mechanism (biology · Prefrontal cortex · Psychosis · Schizophrenia (object-oriented programming · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Schizophrenia research and treatment

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