Large epigenome-wide association study identifies multiple novel differentially methylated CpG sites associated with suicidal thoughts and behaviors in veterans
Bibliographic Data
| ID | 15530320 |
|---|---|
| Authors | Nathan A Kimbrel (0000-0001-7218-1005, Duke University, corresponding author), Melanie E Garrett (0000-0003-2302-6150, Duke Medical Center), Mariah K Evans (0000-0002-4182-6138, Duke University), Clara Mellows (University of North Carolina at Chapel Hill), Michelle F Dennis (0000-0003-0734-7448, Duke University), Lauren P Hair (Duke University), Michael A Hauser (0000-0003-2667-5420, Duke Medical Center), the VA Mid-Atlantic MIRECC Workgroup (Durham VA Health Care System), Allison E Ashley-Koch (0000-0001-5409-9155, Duke University), Jean C Beckham (0000-0001-8746-8949, Duke University) |
| Year | 2023 |
| Volume | 14 |
| Pages | 1145375-1145375 |
| Publication date | 2023-05-25 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2023.1145375 |
| PMID | 37398583 |
| OpenAlex | W4378231862 |
| Language | EN |
| References cited | 43 |
Taken together, the present findings suggest that SLC4A2 , CDK5 , PDE3A , and RARRES3 may play a role in STB. CDK5, a member of the cyclin-dependent kinase family that is highly expressed in the brain and essential for learning and memory, appears to be a particularly promising candidate worthy of future study; however, additional work is still needed to replicate these finding in independent samples
Biology · CpG site · DNA methylation · dNaM · Gene · Genome-wide association study · Single-nucleotide polymorphism · Adolescent and Pediatric Healthcare · Epigenetics and DNA Methylation · Identity, Memory, and Therapy · Medicine · Genetics
| Citation velocity | historical |
|---|---|
| Highly cited | No |