Resistencia a colistina en cepas de Klebsiella pneumoniae multidrogorresistente del período 2015- 2018 en un hospital materno perinatal de Lima, Perú

Bibliographic Data

ID15533727
AuthorsAndrea Naomi-Matsuoka (0000-0003-0954-9561, Universidad Científica del Sur, corresponding author), Marina Vargas (0000-0003-2029-8118, Universidad Científica del Sur), Barbara Ymaña (0000-0002-6482-9243, Universidad Científica del Sur), Gabriela Soza (Perinatal Institute), María J Pons (0000-0001-8384-2315, Universidad Científica del Sur)
Year2020
Volume37
Issue4
Pages716-20
Publication date2020-10-06
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueRevista Peruana de Medicina Experimental y Salud Pública (JOURNAL)
Journal identifiersISSN: 1726-4634 • E-ISSN: 1726-4642
PublisherNational Institute of Health of Peru (PUBLISHER • PE)
DOI10.17843/rpmesp.2020.374.5422
PMID33566913
OpenAlexW3111671909
LanguageES
References cited3

The objective of this study was to evaluate the presence of colistin- and carbapenemic-resistant genes in multidrug-resistant Klebsiella pneumoniae strains isolated at the Instituto Materno Perinatal de Lima (2015-2018). Susceptibility levels were analyzed by disk diffusion and microdilution. The presence of colistin- and carbapenemic-resistant genes was determined by polymerase chain reaction (PCR) and was related to clonality. A total of 36 K. pneumoniae strains were analyzed, 5 (13.8%) were resistant to colistin and belonged to different clonal groups. Only 2 strains were found with carbapenemases (bla KPC and bla NDM), and no colistin plasmid genes were detected. High resistance levels to the other tested antimicrobials were observed, except for amikacin (13.9%). The results highlight the presence of colistin-resistant strains (33.3% in 2018), a worrying situation as they are part of the latest treatment alternatives for infections caused by multiresistant pathogens

Biology · Gene · Klebsiella pneumoniae · Neonatal and Maternal Infections · Genetics

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