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Which modifiable prenatal factors mediate the relation between socio‐economic position and a child's weight and length at birth

Bibliographic Data

ID15535522
AuthorsMorgane Ballon (0000-0003-0584-2795, Inserm, corresponding author), Jérémie Botton (0000-0002-4814-6370, Délégation Paris 5), Anne Forhan (Inserm), Blandine de Lauzon-Guillain (0000-0001-5887-8842, Inserm), Maria Melchior (0009-0006-2018-1373, Inserm), Fabienne El Khoury (Sorbonne Université), Fabienne El-Khoury (0000-0002-6915-6850, Inserm), Aurélie Nakamura (0000-0002-2843-3364, Inserm), Marie Aline Charles (Université de Paris, CRESS, INSERM, INRA F‐75004 Paris), Marie-Aline Charles (0000-0003-4025-4390, Inserm), Sandrine Lioret (0000-0002-2483-7820, Inserm), Bénédicte Heude (0000-0002-1565-1629, Inserm)
Year2019
Volume15
Issue4
Pagese12878-e12878
Publication date2019-07-25
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueMaternal and Child Nutrition (JOURNAL)
Journal identifiersISSN: 1740-8695 • E-ISSN: 1740-8709
PublisherWiley (PUBLISHER • GB)
DOI10.1111/mcn.12878
PMID31343839
OpenAlexW2963081179
LanguageEN
Citations received3
References cited41

Although several studies have shown a positive association between socio-economic position and size at birth, not enough is known about the modifiable factors that may be involved. We aimed to investigate whether maternal prepregnancy body mass index (BMI), smoking, diet, and depression during pregnancy mediate the positive association between maternal education and birth size. Weight and length z-scores specific for gestational age and sex were calculated for 1,500 children from the EDEN mother-child cohort. A mediation analysis of the associations between maternal education and birth size was conducted with a counterfactual method, adjusted for recruitment centre, parity, maternal height, and age. In the comparison of children of mothers with low versus intermediate education levels, maternal smoking during pregnancy explained 52% of the total effect of education on birth weight. Similar findings were observed with birth length z-score (37%). The comparison of children of mothers with high versus intermediate education levels yielded a non-significant total effect, which masked opposite mediating effects by maternal BMI and smoking during pregnancy on both birth weight and length. Prepregnancy BMI and maternal smoking during pregnancy mediate the positive association between maternal education and birth weight and length z-scores. These mediators, however, act in opposite directions, thereby masking the extent to which healthy prenatal growth is socially differentiated

Birth weight · Body mass index · Cohort · Obstetrics · Pregnancy · Birth, Development, and Health · Demography · Gestational Diabetes Research and Management · Medicine · Pregnancy and preeclampsia studies · Endocrinology · Internal Medicine

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Unique citing works3
Citations per year0,43
Citation span2019 - 2025 (7)
Citation velocityrecent
Highly citedNo
Citation typesNeutral: 3

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