Supplementary feeding and infection control in pregnant adolescents—A secondary analysis of a randomized trial among malnourished women in Sierra Leone

Bibliographic Data

ID15535648
AuthorsAminata Shamit Koroma (0000-0001-9288-8542, Ministry of Health and Sanitation), Mariama Ellie (Ministry of Health), Kadiatu Bangura (Ministry of Health), Per Ole Iversen (0000-0003-2977-9153), D Taylor Hendrixson (0000-0003-0627-3571, University of Washington), Kevin B Stephenson (0000-0003-4284-1062, Washington University in St. Louis), Kevin Stephenson (Department of Medicine Washington University in St. Louis St. Louis Missouri USA), Mark J Manary (0000-0003-2733-9568, Washington University in St. Louis, corresponding author)
Year2022
Volume19
Issue1
Pagese13456-e13456
Publication date2022-11-09
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueMaternal and Child Nutrition (JOURNAL)
Journal identifiersISSN: 1740-8695 • E-ISSN: 1740-8709
PublisherWiley (PUBLISHER • GB)
DOI10.1111/mcn.13456
PMID36349973
OpenAlexW4308605955
LanguageEN
Citations received2
References cited22

Undernutrition during pregnancy in adolescence confers a high risk of maternal morbidity and adverse birth outcomes, particularly in low-resource settings. In a secondary analysis, we hypothesized that younger undernourished pregnant adolescents ( 20 years) from the intervention of supplementary food and anti-infective treatments. The original trial in Sierra Leone enrolled 236 younger adolescents (<18 years), 454 older adolescents (aged 18-19 years), and 741 adults (≥20 years), all with a mid-upper arm circumference ≤23 cm. Younger adolescents had lower final fundal height as well as smaller newborns (-0.3 kg; 95% confidence interval [CI], -0.3, -0.2; p < 0.001) and shorter newborns (-1.1 cm; 95% CI, -1.5, -0.7; p < 0.001) than adults. The intervention's effect varied significantly between maternal age groups: adults benefited more than younger adolescents with respect to newborn birth weight (difference in difference, 166 g; 95% CI, 26, 306; interaction p = 0.02), birth length (difference in difference, 7.4 mm; 95% CI, 0.1, 14.8; interaction p = 0.047), and risk for low birth weight (<2.5 kg) (interaction p = 0.019). The differences in response persisted despite adjustments for maternal anthropometry, the number of prior pregnancies, and human immunodeficiency virus status. Older adolescents similarly benefited more than younger adolescents, though differences did not reach statistical significance. In conclusion, newborns born to younger adolescent mothers had worse outcomes than those born to adult mothers, and adults and their newborns benefited more from the intervention than younger adolescents

Anthropometry · Birth weight · Confidence interval · Low birth weight · Malnutrition · Obstetrics · Pregnancy · Randomized controlled trial · Sierra leone · Child Nutrition and Water Access · Global Maternal and Child Health · Medicine · Poverty, Education, and Child Welfare · Internal Medicine · Pediatrics

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