Vitamin D deficiency causes rickets in an urban informal settlement in Kenya and is associated with malnutrition
Bibliographic Data
| ID | 15535784 |
|---|---|
| Authors | Kelsey Jones (0000-0002-1237-0127, Kenya Medical Research Institute, corresponding author), C Ulrich Hachmeister, Maureen Khasira (Kenya Medical Research Institute), Lorna Cox (MRC Human Nutrition Research), Inez Schoenmakers (0000-0001-6243-0506, University of East Anglia), Caroline Munyi (German Doctors), H Samira Nassir (German Doctors), Barbara Hünten‐Kirsch (German Doctors), Ann Prentice (0000-0003-0254-6659, MRC Human Nutrition Research), James A Berkley (0000-0002-1236-849X, Nuffield Orthopaedic Centre) |
| Year | 2017 |
| Volume | 14 |
| Issue | 1 |
| Publication date | 2017-05-03 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Maternal and Child Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1740-8695 • E-ISSN: 1740-8709 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1111/mcn.12452 |
| PMID | 28470840 |
| OpenAlex | W2610790648 |
| Language | EN |
| Citations received | 5 |
| References cited | 28 |
The commonest cause of rickets worldwide is vitamin D deficiency, but studies from sub-Saharan Africa describe an endemic vitamin D-independent form that responds to dietary calcium enrichment. The extent to which calcium-deficiency rickets is the dominant form across sub-Saharan Africa and in other low-latitude areas is unknown. We aimed to characterise the clinical and biochemical features of young children with rickets in a densely populated urban informal settlement in Kenya. Because malnutrition may mask the clinical features of rickets, we also looked for biochemical indices of risk in children with varying degrees of acute malnutrition. Twenty one children with rickets, aged 3 to 24 months, were identified on the basis of clinical and radiologic features, along with 22 community controls, and 41 children with either severe or moderate acute malnutrition. Most children with rickets had wrist widening (100%) and rachitic rosary (90%), as opposed to lower limb features (19%). Developmental delay (52%), acute malnutrition (71%), and stunting (62%) were common. Compared to controls, there were no differences in calcium intake, but most (71%) had serum 25-hydroxyvitamin D levels below 30 nmol/L. These results suggest that rickets in young children in urban Kenya is usually driven by vitamin D deficiency, and vitamin D supplementation is likely to be required for full recovery. Wasting was associated with lower calcium (p = .001), phosphate (p < .001), 25-hydroxyvitamin D (p = .049), and 1,25-dihydroxyvitamin D (p = 0.022) levels, the clinical significance of which remain unclear
Malnutrition · Rickets · Vitamin · Vitamin D and neurology · vitamin D deficiency · Wasting · Child Nutrition and Water Access · Medicine · Vitamin C and Antioxidants Research · Vitamin D Research Studies · Internal Medicine · Pediatrics
Childhood malnutrition, rickets, and anemia
Is dietary deficiency of calcium a factor in rickets? Use of current evidence for our understanding of the disease in the past
The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya
Vitamin D deficiency causes rickets in an urban informal settlement in Kenya and is associated with malnutrition
Prevalence and predictors of hypocalcaemia in severe acute malnutrition
| Unique citing works | 5 |
|---|---|
| Citations per year | 0,56 |
| Citation span | 2017 - 2026 (10) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 5 |