Newborn weight change and predictors of underweight in the neonatal period in Guinea‐Bissau, Nepal, Pakistan and Uganda

Bibliographic Data

ID15535808
AuthorsValerie J Flaherman (0000-0003-3117-927X, University of California, San Francisco, corresponding author), Amy Sarah Ginsburg (0000-0002-2291-2276, University of Washington), Victoria Nankabirwa (0000-0002-9952-8942, Makerere University), Augusto Braima da (International Partnership for Human Development), Augusto Braima da Sa (International Partnership for Human Development Bissau Guinea‐Bissau), Alvaro Medel-Herrero (0000-0002-1154-7859, University of California, San Francisco), Alvaro Medel‐Herrero (Department of Pediatrics University of California San Francisco California USA), Earl Schaefer (0000-0003-1004-6814, Penn State Milton S. Hershey Medical Center), Eric Schaefer (Penn State College of Medicine Hershey Pennsylvania USA), Srijana Dongol (Kathmandu University), Akina Shrestha (0000-0003-2902-827X, Kathmandu University), Muhammad Imran Nisar (0000-0002-2378-4720, Aga Khan University), Imran Nisar (Department of Paediatrics and Child Health Aga Khan University Karachi Pakistan), Muddassir Altaf (Aga Khan University), Khushboo Liaquat (Aga Khan University), Benazir Baloch (Aga Khan University), Najeeb Rahman (0000-0003-0098-628X, Aga Khan University), Yasir Shafiq (0000-0003-1576-724X, Aga Khan University), Shabina Ariff (0000-0002-9627-2662, Aga Khan University), Fyezah Jehan (0000-0002-5874-4358, Aga Khan University), Susan B Roberts (0000-0003-1320-8460, Tufts University)
Year2022
Volume18
Issue4
Pagese13396-e13396
Publication date2022-07-12
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueMaternal and Child Nutrition (JOURNAL)
Journal identifiersISSN: 1740-8695 • E-ISSN: 1740-8709
PublisherWiley (PUBLISHER • GB)
DOI10.1111/mcn.13396
PMID35821647
OpenAlexW4285092739
LanguageEN
Citations received3
References cited27

In low- and middle-income countries (LMIC), growth impairment is common; however, the trajectory of growth over the course of the first month has not been well characterised. To describe newborn growth trajectory and predictors of growth impairment, we assessed growth frequently over the first 30 days among infants born ≥2000 g in Guinea-Bissau, Nepal, Pakistan and Uganda. In this cohort of 741 infants, the mean birth weight was 3036 ± 424 g. For 721 (98%) infants, weight loss occurred for a median of 2 days (interquartile range, 1-4) following birth until weight nadir was reached 5.9 ± 4.3% below birth weight. At 30 days of age, the mean weight was 3934 ± 592 g. The prevalence of being underweight at 30 days ranged from 5% in Uganda to 31% in Pakistan. Of those underweight at 30 days of age, 56 (59%) had not been low birth weight (LBW), and 48 (50%) had reached weight nadir subsequent to 4 days of age. Male sex (relative risk [RR] 2.73 [1.58, 3.57]), LBW (RR 6.41 [4.67, 8.81]), maternal primiparity (1.74 [1.20, 2.51]) and reaching weight nadir subsequent to 4 days of age (RR 5.03 [3.46, 7.31]) were highly predictive of being underweight at 30 days of age. In this LMIC cohort, country of birth, male sex, LBW and maternal primiparity increased the risk of impaired growth, as did the modifiable factor of delayed initiation of growth. Interventions tailored to infants with modifiable risk factors could reduce the burden of growth impairment in LMIC

Birth weight · Cohort · Cohort study · Low birth weight · Obesity · Overweight · Pregnancy · Underweight · Child Nutrition and Feeding Issues · Child Nutrition and Water Access · Demography · Infant Nutrition and Health · Medicine · Internal Medicine · Pediatrics

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