Maternal folate, one‐carbon metabolism and pregnancy outcomes

Bibliographic Data

ID15535813
AuthorsTanja Jankovic‐Karasoulos (0000-0003-4293-359X, Flinders University), Denise Furness (The University of Adelaide), Denise L Furness (Robinson Research Institute University of Adelaide Adelaide South Australia Australia), Shalem Y Leemaqz (0000-0003-4616-8426, Flinders University), Gustaaf A Dekker (Robinson Research Institute University of Adelaide Adelaide South Australia Australia), Gustaaf Dekker (0000-0002-7362-6683, Lyell McEwin Hospital), Luke E Grzeskowiak (0000-0001-8554-4696, The University of Adelaide), Jessica A Grieger (0000-0003-1515-948X, The University of Adelaide), Prabha Andraweera (0000-0003-2434-8370, The University of Adelaide), Dylan McCullough (0000-0002-4510-3797, Flinders University), Dale McAninch (0000-0001-9735-6553, The University of Adelaide), Lesley McCowan (0000-0001-9915-7873, University of Auckland), Lesley M McCowan (Department of Obstetrics and Gynaecology University of Auckland Auckland New Zealand), Tina Bianco‐Miotto (0000-0002-8431-5338, Wine Australia), Claire T Roberts (0000-0002-9250-2192, Flinders University, corresponding author)
Year2020
Volume17
Issue1
Pagese13064-e13064
Publication date2020-07-28
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueMaternal and Child Nutrition (JOURNAL)
Journal identifiersISSN: 1740-8695 • E-ISSN: 1740-8709
PublisherWiley (PUBLISHER • GB)
DOI10.1111/mcn.13064
PMID32720760
OpenAlexW3046177493
LanguageEN
Citations received2
References cited61

Single nucleotide polymorphisms and pre- and peri-conception folic acid (FA) supplementation and dietary data were used to identify one-carbon metabolic factors associated with pregnancy outcomes in 3196 nulliparous women. In 325 participants, we also measured circulating folate, vitamin B12 and homocysteine. Pregnancy outcomes included preeclampsia (PE), gestational hypertension (GHT), small for gestational age (SGA), spontaneous preterm birth (sPTB) and gestational diabetes mellitus (GDM). Study findings show that maternal genotype MTHFR A1298C(CC) was associated with increased risk for PE, whereas TCN2 C766G(GG) had a reduced risk for sPTB. Paternal MTHFR A1298C(CC) and MTHFD1 G1958A(AA) genotypes were associated with reduced risk for sPTB, whereas MTHFR C677T(CT) genotype had an increased risk for GHT. FA supplementation was associated with higher serum folate and vitamin B12 concentrations, reduced uterine artery resistance index and increased birth weight. Women who supplemented with -1 vs. 31.9 ± 11.2, P = .007). Fast food consumption was associated with increased risk for developing GDM, whereas low consumption of green leafy vegetables and fruit were independent risk factors for SGA and GDM and sPTB and SGA, respectively. In conclusion, maternal and paternal genotypes, together with maternal circulating folate and homocysteine concentrations, and pre- and early-pregnancy dietary factors, are independent risk factors for pregnancy complications

Genotype · Gestation · Gestational diabetes · Gynecology · Homocysteine · Methylenetetrahydrofolate reductase · Obstetrics · Preeclampsia · Pregnancy · Small for gestational age · Vitamin B12 · Birth, Development, and Health · Folate and B Vitamins Research · Medicine · Pregnancy and preeclampsia studies · Biochemistry · Internal Medicine

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