Characteristics of infant formula consumed in the first months of life and allergy in the Eden mother–child cohort
Bibliographic Data
| ID | 15536582 |
|---|---|
| Authors | Moufidath Adjibade (0000-0003-2433-3582, Inserm), Lucille Vigneron (Inserm), Rosalie Delvert (0000-0002-1524-8071, Inserm), Karine Adel‐Patient (0000-0002-2242-0626, Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Amandine Divaret‐Chauveau (0000-0002-2492-9864, Hôpital d'Enfants), Isabella Annesi Maesano (0000-0002-6340-9300, Inserm), Isabella Annesi‐Maesano (Desbrest Institute of Epidemiology and Public Health (IDESP), Montpellier University and INSERM Montpellier France), Bénédicte Heude (0000-0002-1565-1629, Inserm), Marie-Aline Charles (0000-0003-4025-4390, Inserm), Blandine de Lauzon-Guillain (0000-0001-5887-8842, Inserm, corresponding author) |
| Year | 2024 |
| Volume | 20 |
| Issue | 4 |
| Pages | e13673-e13673 |
| Publication date | 2024-05-24 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Maternal and Child Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1740-8695 • E-ISSN: 1740-8709 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1111/mcn.13673 |
| PMID | 38786654 |
| OpenAlex | W4398783800 |
| Language | EN |
| Citations received | 2 |
| References cited | 35 |
The evidence regarding the association between infant formula (IF) composition and the prevention of allergy and respiratory diseases remains sparse and inconclusive. This study aimed to evaluate whether some IF characteristics were associated with the risk of allergy or respiratory diseases in childhood. Among 1243 formula-fed children from the EDEN mother-child cohort, IF characteristics concerning long-chain polyunsaturated fatty acids (LCPUFAs) enrichment, prebiotic/probiotic enrichment, and hydrolysis of proteins were identified from the ingredients list. Eczema, wheezing, food allergy, asthma, and allergic rhinitis up to age 8 years were prospectively collected and summarized into four allergic and respiratory multimorbidity clusters. Associations between 4-month IF characteristics and risk of allergy or respiratory diseases were tested using logistic regressions adjusted on main confounders. The consumption of LCPUFA-enriched formula was not linked to allergic and respiratory multimorbidity clusters, but to a lower risk of any allergy, eczema, and wheezing. Probiotic-enriched formula consumption was associated with a lower risk of belonging to the 'Allergy without asthma' cluster (odds ratio [OR] [95% confidence interval, CI] = 0.63 [0.40-0.99]), and consumption of a formula enriched in Bifidobacterium lactis was associated with a lower risk of any allergy (OR [95% CI] = 0.59 [0.41-0.85]). Partially hydrolysed formula (pHF) consumption was associated with a higher risk of belonging to the 'Allergy without asthma' cluster (OR [95% CI] = 2.73 [1.65-4.51]). This study confirms the positive association between pHF consumption and the risk of allergy found in previous observational studies and suggests that consumption of LCPUFA-enriched or probiotic-enriched formula was associated with a lower risk of allergy
Allergy · Asthma · Cohort · Cohort study · Confidence interval · Confounding · Food allergy · Infant formula · Lower risk · Milk allergy · Odds ratio · Breastfeeding Practices and Influences · Child Nutrition and Feeding Issues · Infant Nutrition and Health · Medicine · Immunology · Internal Medicine · Pediatrics
| Citations per year | 1 |
|---|---|
| Citation span | 2024 - 2024 (1) |
| Highly cited | No |