The association of breastfeeding with insulin resistance at 17 years

Prospective observations from Hong Kong's “ C hildren of 1997” birth cohort

Bibliographic Data

ID15536995
AuthorsLai Ling Hui (0000-0003-0688-3329, Chinese University of Hong Kong, corresponding author), Man Ki Kwok (0000-0003-3777-4766, University of Hong Kong), E A S Nelson (0000-0002-2521-3403, Chinese University of Hong Kong), So Lun Lee (0000-0001-7158-3651, Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong), So-Lun Lee (0000-0003-3056-9778, University of Hong Kong), Gabriel M Leung (School of Public Health, Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong), Genevieve Leung (0000-0002-2503-6283, University of Hong Kong), C Mary Schooling (0000-0001-9933-5887, University of Hong Kong)
Year2017
Volume14
Issue1
Publication date2017-08-04
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueMaternal and Child Nutrition (JOURNAL)
Journal identifiersISSN: 1740-8695 • E-ISSN: 1740-8709
PublisherWiley (PUBLISHER • GB)
DOI10.1111/mcn.12490
PMID28776916
OpenAlexW2743755370
LanguageEN
Citations received1
References cited32

Breastfeeding has many benefits for mother and infant. Whether breastfeeding also protects against type 2 diabetes is unclear. To clarify the role of breastfeeding in type 2 diabetes, we assessed the association of breastfeeding with insulin resistance in late adolescence in a birth cohort from a non-Western setting where breastfeeding was not associated with higher socio-economic position. We used multivariable linear regression, with multiple imputation and inverse probability weighting, to examine the adjusted associations of contemporaneously reported feeding in the first 3 months of life (exclusively breastfed, mixed feeding, or always formula-fed) with fasting glucose, fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) at 17 years in a subset (n = 710, 8.6% of entire cohort) of the Hong Kong Chinese birth cohort "Children of 1997." We found a graded association of breastfeeding exclusivity in the first 3 months of life with lower fasting insulin and HOMA-IR (p-for-trend < .05), but not fasting glucose, at 17 years. Exclusively breastfed adolescents (7%) had nonsignificantly lowest fasting insulin and HOMA-IR, adjusted for sex, birth weight, parity, length of gestation, pregnancy characteristics, parents' education, and mother's place of birth. Exclusively breastfeeding for 3 months may be causally associated with lower insulin resistance in late adolescence. Further follow-up studies into adulthood are required to clarify the long-term protection of breastfeeding from type 2 diabetes

Breast feeding · Breastfeeding · Cohort · Cohort study · Diabetes mellitus · Insulin · Insulin resistance · Obstetrics · Prospective cohort study · Type 2 diabetes · Breastfeeding Practices and Influences · Demography · Gestational Diabetes Research and Management · Medicine · Obesity, Physical Activity, Diet · Endocrinology · Internal Medicine · Pediatrics

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