Interactive effects of air pollutants and temperature on incidence of dementia

A prospective cohort study

Bibliographic Data

ID15548813
AuthorsJiali Wang (0000-0002-0781-8177, Central South University), Yinyan Gao (0000-0002-0518-4166, Central South University), Yijuan Lin (Central South University), Xuemei Sun (0000-0002-4501-7098, Central South University), Shuzi Ye (0000-0002-4841-4507, Central South University), Yan Shi (0000-0003-0320-3244, Central South University), Xin Yin Wu (0000-0003-3772-2376, Central South University), Irene X Y Wu, Wenjie Dai (0000-0002-0922-7223, Central South University), Fang Xiao (0000-0002-6814-1227, Central South University, corresponding author)
Year2023
Volume18
Issue7
Pages074034-074034
Publication date2023-06-19
Open AccessYes
TypeARTICLE
VenueEnvironmental Research Letters (JOURNAL)
Journal identifiersISSN: 1748-9326 • E-ISSN: 1748-9326
PublisherIOP Publishing (PUBLISHER • GB)
DOI10.1088/1748-9326/acdf73
OpenAlexW4381187582
LanguageEN
References cited46

Mounting evidence has linked air pollution with dementia and temperature modifies the association of air pollution with other disease. However, their interactions on dementia are unclear. We used a prospective cohort study (the UK Biobank) included 498 660 adults without cognitive impairment or dementia at baseline and followed up for 11.50 years (5734 907 person-years). We applied Cox proportional hazards regression with time-varying exposures to examine the effects of air pollutants [particulate matter (PM 2.5 , PM 10 ), nitrogen oxides (NO 2 , NO X ) and sulphur dioxide (SO 2 )], the mean and variability of seasonal temperature, and their interactions on dementia. During the follow-up time, we ascertained 4119 cases of dementia. We observed a higher hazard of incident dementia for 1 μ g m −3 increase in SO 2 (hazard ratio [HR] = 1.11; 95% confidence interval [CI]: 1.08, 1.14), NO 2 (HR [95% CI] = 1.02 [1.01, 1.02]), NO X (HR [95% CI] = 1.01 [1.00, 1.01]), PM 2.5 (HR [95% CI] = 1.03 [1.02, 1.05]), and PM 10 (HR HR [95% CI] = 1.02 [1.00, 1.03]). A lower risk of dementia in summertime temperature variability (HR for 1 °C increment above 1.27 °C = 0.61; 95% CI: 0.51, 0.72) was found. We observed a nonlinear relationship between higher risk of dementia and higher summer temperatures, and strong U-shaped relation of both wintertime temperature and wintertime temperature variability with dementia. We found the significantly synergistic effect between SO 2 and summertime temperature ( p < 0.001), the antagonistic effect between NO 2 ( p = 0.043), NO X ( p = 0.026) and summertime temperature variability. Participants in a lower social economic position dominated susceptibility in temperature-air pollution interaction on dementia. In conclusion, some evidence of interactive effects between summer temperature and air pollutants was found, but no consistent interaction could be identified during the winter. Our study added weight to the evidence of air pollutants, temperature and their interaction on the onset of dementia

Cohort · Cohort study · Confidence interval · Dementia · Disease · Hazard ratio · Incidence (geometry · Proportional hazards model · Prospective cohort study · Air Quality and Health Impacts · Climate Change and Health Impacts · Global Health Care Issues · Medicine · Internal Medicine

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