Association between Serum Total and Specific Immunoglobulin E Levels and Body Height
A Cross-Sectional Study of Children and Adolescents
Bibliographic Data
| ID | 15714138 |
|---|---|
| Authors | Ling‐Sai Chang (0000-0002-3591-1563, Chang Gung University), Ling-Sai Chang (Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan), Jou-Hui Li (Kaohsiung Chang Gung Memorial Hospital), Peiming Wang (0000-0002-1386-5746, Kaohsiung Chang Gung Memorial Hospital), Pei-Ming Wang (Department of Family Medicine, Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan), Chih-Fang Huang (0000-0002-5900-292X, Kaohsiung Chang Gung Memorial Hospital), Ho‐Chang Kuo (0000-0002-3295-2984, Kaohsiung Chang Gung Memorial Hospital, corresponding author) |
| Year | 2022 |
| Volume | 9 |
| Issue | 5 |
| Pages | 661-661 |
| Publication date | 2022-05-04 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children9050661 |
| PMID | 35626838 |
| OpenAlex | W4225393595 |
| Language | EN |
| Citations received | 2 |
| References cited | 45 |
Background: The atopy rate in children has increased significantly. Atopy and growth are connected in a multifactorial manner and are important health issues for children around the world. The principal research question in this cross-sectional investigation concerned the association between serum total, specific immunoglobulin E (IgE) levels, and body height (BH)/weight (BW)/body mass index (BMI). Methods: A total of 993 subjects were enrolled for analysis retrospectively with allergic diseases and aged from 6 months to 18 years during the years 2015−2016. A complete panel of 36 allergen-specific IgE was taken from each participant using the MAST allergen test as well as their BH, BW, BMI, and total IgE levels. Results: There was a statistically significant positive association between the total IgE levels with BH (N = 348) and BW (N = 623) in the preschool age group (<6 years old, p-values of 0.009 and 0.034, respectively). In the preschool group, the total IgE levels showed a positive association with house dust (p < 0.001), cockroach mix (p < 0.001), Dermatophagoides farina (p < 0.001), and Dermatophagoides pteronyssinus (p < 0.001). After performing a general linear model followed by a backward selection of variables with age, sex, specific IgE, and total IgE, egg white sensitization demonstrated a significant negative association with BH (p = 0.009), and Dermatophagoides farina sensitization showed a significant positive association with BH (p = 0.006). The analysis showed that, in this model, the level of total IgE was not associated with BH. Conclusions: The results of this study indicate that the level of total IgE was not associated with BH in the preschool age group. Future studies are needed to replicate the results in outcome with follow-up allergic cohorts
Allergen · Allergy · Antibody · Atopy · Body mass index · Cross-sectional study · Immunoglobulin E · Pathology · Sensitization · Allergic Rhinitis and Sensitization · Asthma and respiratory diseases · Food Allergy and Anaphylaxis Research · Medicine · Immunology · Internal Medicine
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| Citations per year | 0.67 |
|---|---|
| Citation span | 2023 - 2023 (1) |
| Highly cited | No |