Helicobacter pylori Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional Study

Bibliographic Data

ID15718652
AuthorsMarek Walkowiak (Poznan University of Medical Sciences), Łukasz Kałużny (Poznan University of Medical Sciences), Renata Mozrzymas (Łukasiewicz Research Network – PORT Polish Center for Technology Development), Małgorzata Jamka (0000-0002-0257-6180, Poznan University of Medical Sciences), Bożena Mikołuć (0000-0002-8284-6426, Medical University of Białystok), Joanna Jagłowska (Gdańsk Medical University), Ewa Starostecka (Polish Mother’s Memorial Hospital Research Institute), Roza Nurgaliyeva (West Kazakhstan Marat Ospanov State Medical University), Jaroslaw Walkowiak (0000-0001-5813-5707, Poznan University of Medical Sciences), Aleksandra Lisowska (0000-0002-5453-4716, Poznan University of Medical Sciences, corresponding author)
Year2021
Volume8
Issue8
Pages713-713
Publication date2021-08-19
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children8080713
PMID34438604
OpenAlexW3196152011
LanguageEN
References cited1

In a small preliminary study, phenylketonuria and poor metabolic control were suggested as risk factors for Helicobacter pylori infection in children as detected with an antigen stool test. We aimed to determine Helicobacter pylori prevalence in an adequately sized group of individuals with phenylketonuria and healthy subjects using the standard gold test (urea breath test). Further, we correlated Helicobacter pylori infection with metabolic control. The study comprised 103 individuals with phenylketonuria and 103 healthy subjects on whom a 13 C urea breath test was performed. Blood phenylalanine levels in the preceding year were analysed. The infection rate did not differ between individuals with phenylketonuria and healthy subjects (10.7% vs 15.5%; p = 0.41). The frequency of testing and phenylalanine concentrations of Helicobacter pylori -positive and Helicobacter pylori -negative patients with phenylketonuria did not differ ( p = 0.92 and p = 0.54, respectively). No associations were detected for body mass index or metabolic control. Forward stepwise regression models revealed that age ( p = 0.0009-0.0016) was the only independent correlate of Helicobacter pylori infection with a relatively low fraction of the variability of the condition being explained (adjR 2 = 0.0721-0.0754; model p = 0.020-0.023). In conclusion, Helicobacter pylori infection in phenylketonuria is not more frequent than in the general population. Moreover, it does not depend on metabolic control

Body mass index · Breath test · Case-control study · Helicobacter · Helicobacter pylori · Helicobacter pylori infection · Metabolic control analysis · Population · Urea breath test · Diet, Metabolism, and Disease · Helicobacter pylori-related gastroenterology studies · Medicine · Metabolism and Genetic Disorders · Gastroenterology · Immunology · Internal Medicine

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