Lipid Profile and Triglyceride-Glucose Index (TyG) Alterations in a Single-Center Cohort of Children Diagnosed with Central Precocious Puberty

Bibliographic Data

ID15719356
AuthorsGiorgio Sodero (0000-0003-3711-4928, Agostino Gemelli University Polyclinic), Lucia Celeste Pane (Agostino Gemelli University Polyclinic), Elena Malavolta (Agostino Gemelli University Polyclinic), Giulia Rotunno (0000-0003-4239-5816, Agostino Gemelli University Polyclinic), Linda Sessa (Agostino Gemelli University Polyclinic), Barbara Fraccascia (Agostino Gemelli University Polyclinic), Marcello Candelli (0000-0001-8443-7880, Agostino Gemelli University Polyclinic), Donato Rigante (0000-0001-7032-7779, Agostino Gemelli University Polyclinic, corresponding author), Clelia Cipolla (Agostino Gemelli University Polyclinic)
Year2024
Volume11
Issue6
Pages639-639
Publication date2024-05-25
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children11060639
PMID38929219
OpenAlexW4399041352
LanguageEN
References cited31

Background: A correlation between plasma lipids and timing of pubertal development has been hypothesized, though lipid influence remains unclear in central precocious puberty (CPP). Aim: To assess any possible alterations in the lipid profile and triglyceride glucose index (TyG) in children diagnosed with CPP. Patients and Methods: Retrospective single-center study conducted on children (aged 6.3 ± 2.1 years) evaluated for the suspicion of CPP. Results: Based on the results of the gonadotropin releasing hormone (GnRH) test, considering 5 IU/L as cut-off of the luteinizing hormone peak, CPP was confirmed in 43 patients (57.3%). Sixteen (37.2%) had a pathologic body mass index (BMI), with 9 (20.9%) being overweight and 7 (16.27%) obese. High total cholesterol was found in 3 patients with CPP (6.97%), high triglycerides were found in 11 patients with CPP (25.58%), high LDL cholesterol was found in 5 patients with CPP (11.62%), low HDL cholesterol was found in 12/43 patients with CPP (27.9%), a pathologic TyG was found in 13/43 patients with CPP (30.23%). No significant association was observed in the lipid profile for patients with or without CPP, except for HDL cholesterol, which was lower in the CPP group (47.1 ± 10.9; p = 0.033). However, the association between serum HDL cholesterol and CPP was not confirmed at the multivariate logistic regression analysis adjusted for patients' sex and age ( p = 0.1; OR: 1.035; 95% CI: 0.993-1.078). Conclusion: The overall lipid profile of our pediatric patients diagnosed with CPP did not differ from patients having idiopathic precocious thelarche or normal variants of puberty development

Body mass index · Cholesterol · Lipid Profile · Overweight · Triglyceride · Birth, Development, and Health · Growth Hormone and Insulin-like Growth Factors · Hypothalamic control of reproductive hormones · Medicine · Endocrinology · Gastroenterology · Internal Medicine

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