Mechanisms of ginseng in pancreatic cancer metastasis

A network pharmacology analysis

Bibliographic Data

ID15795407
AuthorsSheng‐Zhang Lin (City University of Macau, corresponding author), Shengzhang Lin, Zhaohong Wang (0009-0003-3871-130X, Wenzhou Medical University, corresponding author), Xufan Cai (Zhejiang Chinese Medical University, corresponding author)
Year2023
Volume7
Issue3
Pages67-75
Publication date2023-10-08
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Health Sciences (JOURNAL)
Journal identifiersISSN: 2550-696X • E-ISSN: 2550-6978
PublisherUniversidad Tecnica de Manabi (PUBLISHER • EC)
DOI10.53730/ijhs.v7n3.14490
OpenAlexW4387603655
LanguageEN
Citations received1
References cited7

It has been shown that ginsenosides can inhibit proliferation, migration, and invasion of pancreatic cancer (PC) cells, and promote apoptosis of PC cells. However, the potential mechanisms of ginseng in treating PC metastasis (PCM) have not been fully elucidated. In this study, we employed an integrated bioinformatics approach of network pharmacology analysis. By selecting common targets of diseases and drugs, a drug-component-target-disease network was constructed to analyze the biological functions and signaling pathways involved in the targets. A total of 6 PC samples were includedd, which were divided into primary PC group (PANC-1, n=3) and metastatic PC group. A total of 9263 differentially expressed genes (DEGs) and 14 PC target genes were identified. According to the network pharmacology analysis, we found that ginsenoside Rg3 was associated with the treatment of PCM and identified 6 potential targets. Among them, CD44, EGFR, KRAS, and PRNP were the main DEGs related to the treatment of PC by ginsenoside Rg3. These genes were mainly enriched in the Proteoglycans in Cancer pathway, and KRAS, EGFR, and CD44 were upregulated in the pathway, which may be affected by the ginsenoside Rg3. This provides a new direction for further research on the mechanisms of ginseng in PCM

Biology · Cancer · CD44 · Cell · Downregulation and upregulation · Gene · Ginseng · Ginsenoside · KRAS · Metastasis · Pancreatic cancer · Pathology · Signal transduction · Ferroptosis and cancer prognosis · Ginseng Biological Effects and Applications · Medicine · Sphingolipid Metabolism and Signaling · Cancer Research · Cell Biology · Genetics · Internal Medicine · Pharmacology

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