Inflammatory markers and occurrence of falls

Bibliographic Data

ID16780203
AuthorsJuleimar Soares Coelho De Amorim (0000-0003-3218-1769, Fundação Oswaldo Cruz), Karen Cecília Lima Torres (0000-0002-2943-4350, Fundação Oswaldo Cruz), Andréa Teixeira-Carvalho (0000-0003-2814-5183, Fundação Oswaldo Cruz), Olindo Assis Martins-Filho (0000-0002-5494-4889, Fundação Oswaldo Cruz), Maria Fernanda Furtado Lima-Costa (0000-0002-3474-2980, Fundação Oswaldo Cruz), Sérgio William Viana Peixoto (0000-0001-9431-2280, Universidade Federal de Minas Gerais)
Year2019
Volume53
Pages35
Publication date2019-03-26
Open AccessYes
TypeARTICLE
VenueRevista de Saúde Pública (JOURNAL)
Journal identifiersISSN: 0034-8910 • E-ISSN: 0034-8910
PublisherUniversidade de São Paulo. Agência de Bibliotecas e Coleções Digitais (PUBLISHER)
DOI10.11606/s1518-8787.2019053000855
PMID30942277
OpenAlexW2928106214
LanguageEN
Citations received2
References cited9

OBJECTIVE: Analyze whether inflammatory markers are associated with falls among older adults living in Bambuí. METHODS: Study that analyzed baseline data from a Bambuí Cohort Study of Aging, involving 1,250 participants. Data about falls were collected from previous 12 months, classified as single or multiple occurrence and severity (participant seeking health services). Information about sociodemographic characteristics, health behaviors and health condition was also collected and used as confounding factors. The exposures of interest included interleukins (IL-1β, IL-6, IL-8, IL-10, IL-12), tumor necrosis factor (TNF), ultra-sensitive C-reactive protein (us-CRP) and chemokines (CXCL9, CCL5, CCL10, MCP1). Data were processed through logistic regression, obtaining odds ratio and 95% confidence interval (95%CI). RESULTS: The prevalence of falls was 27.1%; 40.1% of the older adults reported multiple falls and 33.3% sought health services. After adjustments, the following elevated levels were associated with falls: us-CRP (OR = 1.46, 95%CI 1.04–2.03), CCL5 (OR = 1.38, 95%CI 1.01–1.90) and CXCL9 (OR = 1.43, 95%CI 1.02–2.02). An association was observed between the number of elevated markers and the occurrence of falls: two (OR = 1.47, 95%CI 1.02–2.12) and three (OR = 2.08, 95%CI 1.12–3.87) elevated biomarkers indicated fall probability of 32.0% and 39.4%, respectively. CONCLUSIONS: Elevated levels of us-CRP, CCL5 and CXCL9, which were associated with falls, may contribute to a proper understanding of the mechanism associated with the occurrence of falls among older people

Balance, Gait, and Falls Prevention · Chronic Obstructive Pulmonary Disease (COPD) Research · Medicine · Nutrition and Health in Aging

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