Relationship between Vitamin D Insufficiency, Lipid Profile and Atherogenic Indices in Healthy Women Aged 18–50 Years

Bibliographic Data

ID16945974
AuthorsIlham Lhilali (0009-0000-1557-1250, Instituts Supérieurs des Professions Infirmières et Techniques de Santé, corresponding author), Noura Zouine (0000-0002-2753-3267, Instituts Supérieurs des Professions Infirmières et Techniques de Santé), Lode Godderis (0000-0003-4764-8835, KU Leuven), Adil El Midaoui (Université Moulay Ismail de Meknes), Samir El Jaâfari (Université Moulay Ismail de Meknes), Younes Filali-Zegzouti (0000-0002-8607-0258, Université Moulay Ismail de Meknes)
Year2024
Volume14
Issue8
Pages2337-2357
Publication date2024-08-09
Open AccessYes
TypeARTICLE
VenueEuropean Journal of Investigation in Health, Psychology and Education (JOURNAL)
Journal identifiersISSN: 2174-8144 • E-ISSN: 2254-9625
PublisherMDPI AG (PUBLISHER • IT)
DOI10.3390/ejihpe14080155
PMID39194949
OpenAlexW4401483921
LanguageEN
References cited100

Although vitamin D insufficiency has been correlated with an increased risk of cardiovascular disease (CVD), there are few data on the association between 25-hydroxyvitamin D (25(OH)D) and atherogenic indices predictive of CVD. This study investigated the relationship of vitamin D status with lipid profile and atherogenic indices in adult women in Morocco. Three hundred women aged 18 to 50 years from Meknes were included. Fasting 25(OH)D and lipid concentrations were assayed by a one-step electrochemiluminescence-based immunoassay and an enzymatic method, respectively. Atherogenic indices (atherogenic index of plasma (AIP), atherogenic coefficient (AC), non-HDL cholesterol (non-HDL-C), Castelli risk indices I and II (CRI-I and II), and CHOLIndex (CI)) were calculated using conventional lipid parameters. Logistic regression models and operating characteristic curve (ROC) analysis were used to assess the relationship of the variables and estimate the threshold of 25(OH)D levels associated with high atherogenic indices. 25(OH) D below 20 ng/mL was significantly associated with an enhanced risk of hypertriglyceridemia and elevated values of AIP, AC, non-HDL-C, and CRI-I with an OR (95% CI) of 4.904 (1.856–12.959), 3.637 (2.149–6.158), 3.589 (1.673–7.700), 2.074 (1.215–3.540), and 2.481 (1.481–4.123), respectively. According to the ROC analysis, the likelihood of hypertriglyceridemia and high values of AIP, AC, non-HDL-C, and CRI-I were associated with 25(OH)D thresholds ≤15.15 ng/mL, ≤17.5 ng/mL, ≤19.8 ng/mL, ≤20.1 ng/mL, and ≤19.5 ng/mL, respectively, all p

Cholesterol · Lipid Profile · Vitamin · Vitamin D and neurology · Bone health and osteoporosis research · Demography · Medicine · Menstrual Health and Disorders · Vitamin D Research Studies · Endocrinology · Gerontology · Internal Medicine · Physiology

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