Tryptophan Levels, Excessive Exercise, and Nutritional Status in Anorexia Nervosa
Bibliographic Data
| ID | 19301810 |
|---|---|
| Authors | Angela Favaro (0000-0002-6540-5194, University of Padua), Lorenza Caregaro (University of Padua), Alberto Burlina (0000-0001-7724-137X, University of Padua), Alberto B Burlina, Paolo Santonastaso (0000-0002-7408-0563, University of Padua) |
| Year | 2000 |
| Volume | 62 |
| Issue | 4 |
| Pages | 535-538 |
| Publication date | 2000-07-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/00006842-200007000-00012 |
| PMID | 10949099 |
| OpenAlex | W2002427736 |
| Language | EN |
| Citations received | 3 |
| References cited | 22 |
OBJECTIVE: It has been hypothesized that reduced dietary availability of tryptophan may be the cause of impaired serotonin activity in underweight anorexics. The study reported here evaluated the relationship between tryptophan availability in the blood and nutritional status in anorexia nervosa. METHODS: The total amount of tryptophan and the ratio between tryptophan and other large neutral amino acids (TRP/LNAA) were assessed in a sample of 16 starving anorexic patients. Body weight and composition and energy intake were evaluated in all patients. All subjects also completed self-reported questionnaires such as the Hopkins Symptom Checklist and Eating Disorders Inventory (EDI). RESULTS: The TRP/LNAA ratio seems to be higher in patients with a more severe catabolic status. It is, in fact, significantly inversely correlated with body mass index, body fat, muscle mass, daily energy intake, and daily tryptophan intake. The TRP/LNAA ratio also correlates with growth hormone and the EDI drive for thinness. Patients who exercise excessively had significantly higher TRP/LNAA ratios. CONCLUSIONS: In starving anorexic patients, the TRP/LNAA ratio does not seem to be determined by the content of tryptophan in the diet, but it correlates with measures of catabolism. The relationship of the TRP/LNAA ratio to excessive exercise and starvation indicates the importance of further investigations exploring the role of tryptophan availability in maintaining anorexia nervosa
Amino acid · Anorexia · Anorexia nervosa · Appetite · Body mass index · Catabolism · Eating disorders · Metabolism · Overweight · Psychiatry · Serotonin · Tryptophan · Underweight · Biochemistry · Chemistry · Eating Disorders and Behaviors · Endocrinology · Internal Medicine · Medicine · Neurotransmitter Receptor Influence on Behavior · Psychology · Tryptophan and brain disorders
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Exaggerated feedback control decreases brain serotonin concentration and elicits hyperactivity in a rat model of diet-restriction-induced anorexia nervosa
The Role of Exercise Dependence for the Relationship between Exercise Behavior and Eating Pathology
| Unique citing works | 3 |
|---|---|
| Citations per year | 0,14 |
| Citation span | 2004 - 2009 (6) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 3 |