Serotonergic Changes in Specific Areas of Rat Brain Associated with Activity-Stress Gastric Lesions

To study serotonergic involvement in the development of gastric lesions following activity wheel stress, three groups of rats (gastric lesions, no gastric lesions, and home--cage controls) were killed following exposure to the experimental procedures. The brains were dissected into eight specific areas and subjected to analyses for serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) using high performance liquid chromatography with EC detection. Lower levels of 5-HT were found in the midbrain, cortex, and hippocampus of rats with gastric lesions compared to either the no lesion group, subjected to shorter periods of activity--stress, or the home--cage control group. Levels of 5-HT and 5-HIAA were elevated in the pons/medulla oblongata of both the lesion and the no lesion groups compared to the home--cage controls. Corticosterone levels in blood were also significantly elevated in the lesion group. These data on serotonin changes in the CNS suggest a possible role for this neurotransmitter in stress-induced gastric pathology

5-Hydroxyindoleacetic acid · Biology · Central nervous system · Cortex (anatomy) · Corticosterone · Hippocampus · Lesion · Medulla · Medulla oblongata · Midbrain · Neurotransmitter · Pathology · Pons · Receptor · Serotonergic · Serotonin · Endocrinology · Gastrointestinal motility and disorders · Helicobacter pylori-related gastroenterology studies · Internal Medicine · Medicine · Neuroscience

• Telemetry provides new insights into entrainment of activity wheel circadian rhythms and the role of body temperature in the development of ulcers in the activity-stress paradigm

  Open Access•Helen M Murphy, HELEN MURPHY et al.•Integrative Psychological and…•2002

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