Hippocampal Atrophy in Persons With Age-Associated Memory Impairment
Volumetry Within a Common Space
Bibliographic Data
| ID | 19306164 |
|---|---|
| Authors | Michael S Mega (0000-0002-2155-864X, University of California, Los Angeles), Gary W Small (0000-0001-5601-5402), Mina L Xu (0000-0001-9513-245X), Jenaro Felix, Mario Manese, Nha P Tran, Jason I Dailey, Linda M Ercoli, Susan Y Bookheimer (0000-0002-3417-5891), Arthur W Toga (0000-0001-7902-3755) |
| Year | 2002 |
| Volume | 64 |
| Issue | 3 |
| Pages | 487-492 |
| Publication date | 2002-05-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/00006842-200205000-00013 |
| PMID | 12021422 |
| OpenAlex | W2029495108 |
| Language | EN |
| Citations received | 1 |
| References cited | 36 |
OBJECTIVE: The objective of this study is to demonstrate the assessment of hippocampal atrophy within a standard brain atlas for persons with age-associated memory impairment (AAMI) compared with cognitively intact elderly. METHODS: High-resolution three-dimensional (3D) brain magnetic resonance imaging (MRI) was performed on 20 nondemented persons: 10 had AAMI and 10 were normal elderly. Scans were aligned to a common atlas template to control for errors due to variable brain size and orientation as well as facilitating communication of results across centers. Manual outlining every 1 mm with volumes determined for both the hippocampal head and body was accomplished after coronal resampling perpendicular to the long axis of the hippocampus. RESULTS: Subject groups were similar in age, sex ratios, and educational achievement. The AAMI group had significantly lower volumes for the right hippocampus and hippocampal head (p =.02) compared with controls. CONCLUSION: A growing body of work suggests the right hippocampal head as an early site of atrophy in early memory impairment. Subtle atrophic changes are detectable within a common atlas template allowing imaging assessment across centers
Atrophy · Audiology · Cognition · Coronal plane · Hippocampal formation · Hippocampus · Magnetic resonance imaging · Memory Impairment · Neuroimaging · Pathology · Radiology · Anatomy · Cognitive Functions and Memory · Dementia and Cognitive Impairment Research · Medicine · Memory and Neural Mechanisms · Neuroscience · Psychology
| Citations per year | 0.04 |
|---|---|
| Citation span | 2002 - 2002 (1) |
| Highly cited | No |