Endogenous Cortisol Exposure and Declarative Verbal Memory
A Longitudinal Study of Healthy Older Adults
Bibliographic Data
| ID | 19306541 |
|---|---|
| Authors | Suzanne C Segerstrom (0000-0002-4020-111X, University of Kentucky, corresponding author), Paul J Geiger (0000-0003-4157-5436, University of Kentucky), Ian A Boggero (0000-0001-8891-0292, University of Kentucky), Fredrick A Schmitt (Committee on Publication Ethics), Sandra E Sephton (0000-0003-0585-0277, Committee on Publication Ethics) |
| Year | 2016 |
| Volume | 78 |
| Issue | 2 |
| Pages | 182-191 |
| Publication date | 2016-02-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0000000000000249 |
| PMID | 26569538 |
| OpenAlex | W2461034703 |
| Language | EN |
| Citations received | 2 |
| References cited | 28 |
OBJECTIVE: Exposure to endogenous cortisol is associated with hippocampal degeneration and may contribute to problems with declarative memory, but effects of persistent versus phasic cortisol elevations have not been established. The present longitudinal investigation examined persistent individual differences and phasic changes in cortisol as they related to verbal memory, executive functions, and subjective cognitive function. METHODS: Older adults (n = 132, aged 60-93 years) were followed up for up to 5 years. They were assessed annually for verbal memory and every 6 months for executive functions, subjective cognitive function, and cortisol area under the curve (averaged over 3 days). RESULTS: In multilevel models, persistently but not phasically higher cortisol was associated with worse verbal memory in both learning (t(181) = 2.99, p = .003) and recall (t(280) = 3.10, p = .002). This effect withstood adjustment for stress, depression, metabolic health, and age. There was evidence for attenuated primacy in learning with higher persistent cortisol. Phasic increases in cortisol were not associated with changes in memory, and cortisol was not related to executive functions or subjective cognitive function. CONCLUSIONS: Higher secretion of cortisol may, over time, contribute to memory dysfunction in older adults
Audiology · Cognition · Cognitive psychology · Developmental psychology · Effects of stress on memory · Hippocampus · Hydrocortisone · Memory consolidation · Recall · Verbal learning · Verbal memory · Adrenal Hormones and Disorders · Hormonal Regulation and Hypertension · Internal Medicine · Medicine · Neuroscience · Psychology · Stress Responses and Cortisol
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Centering predictor variables in cross-sectional multilevel models
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| Citations per year | 0.5 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |