The Moderating Effects of Genetic Variations on Changes in Physical Activity Level and Cardiorespiratory Fitness in Response to a Life-Style Intervention

A Randomized Controlled Trial

Bibliographic Data

ID19307105
AuthorsHarold Lee (0000-0001-5778-3227, Miriam Hospital, corresponding author), Harold H Lee, John E McGeary (0000-0003-4025-9511, Island Institute), Shira I Dunsiger (0000-0001-5636-0601, Island Institute), Shira Dunsiger, Laura Baker (0000-0002-9136-7806), Laura D Baker (0000-0002-6217-7384, Island Institute), Ashok Balasubramanyam (0000-0003-2093-5201, Island Institute), William C Knowler (0000-0002-7004-5197, Island Institute), David M Williams (0000-0002-2973-7677, Island Institute)
Year2021
Volume83
Issue5
Pages440-448
Publication date2021-06-01
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0000000000000930
PMID34080585
OpenAlexW3149799976
LanguageEN
References cited38

OBJECTIVE: Prior studies identified single nucleotide polymorphisms (SNPs) associated with physical activity (PA) level in a natural environment and intervention study: rs978656-DNAPTP6, rs10887741-PAPSS2, rs7279064-C18orf2, and rs6265-BDNF. Using the four SNPs' polygenic score (PGS), we examined whether PGS moderates a life-style intervention's effect on changes in PA level and cardiorespiratory fitness (CRF). METHODS: This is a secondary analysis of Look AHEAD, a multicenter randomized controlled trial designed to test the health benefits of a life-style intervention among 2675 participants with overweight/obesity and type 2 diabetes (ages, 45-76 years). Using linear mixed-effects models, level of PA (Paffenbarger PA questionnaire) and treadmill-assessed CRF were each regressed on four SNPs' PGS, study time (baseline, year 1, and year 4), intervention arm, and interactions between the three. Models adjusted for age, sex, body mass index, ancestry principal components (population stratification), and study sites, with Bonferroni corrections for multiple testing (α 55 years for CRF, >60 years for PA level). CONCLUSIONS: The effects of the intervention on PA and CRF were not moderated by the four SNPs. Future studies with extended SNP list should confirm the findings on effect modification by age

Cardiorespiratory fitness · Developmental psychology · Intervention (counseling) · Life style · Physical activity · Physical fitness · Physical therapy · Psychiatry · Psychotherapist · Randomized controlled trial · Style (visual arts) · Clinical Psychology · Genetic Associations and Epidemiology · Genetics and Physical Performance · Internal Medicine · Medicine · Nutrition, Genetics, and Disease · Psychology

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