Stress-Induced Parasympathetic Control and Its Association With Inflammatory Reactivity

Bibliographic Data

ID19307641
AuthorsAlex Woody (0000-0002-0148-8103, Ohio University), Wilson S Figueroa (0000-0002-2540-0161, Ohio University), Fabián Benencia (0000-0003-3049-6150, Ohio University), Peggy M Zoccola (0000-0001-5709-0092, Ohio University, corresponding author)
Year2017
Volume79
Issue3
Pages306-310
Publication date2017-04-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0000000000000426
PMID28002383
OpenAlexW2561002469
LanguageEN
Citations received2
References cited26

OBJECTIVE: It has been proposed that the inflammatory cytokine system is regulated through the vagus nerve, where vagal activation inhibits release of inflammatory cytokines and, therefore, inflammation. Thus, loss of vagal activation (i.e., reduced high-frequency heart rate variability [HF-HRV]) should result in greater inflammation. Evidence to date for this relationship has relied on animal models and resting states in humans. The present study used a psychosocial stressor to test whether stress-induced decreases in HF-HRV predict increases in circulating inflammatory markers. METHODS: Thirty healthy young women completed a speech stressor. HF-HRV was assessed before and during the stressor while circulating plasma interleukin 6, tumor necrosis factor α, and C-reactive protein were assessed before and 1 hour after the stressor. RESULTS: Consistent with the neural reflex for immunity, greater reductions in HF-HRV during the stressor were associated with greater increases in tumor necrosis factor α (β = -0.29 to -0.47) and interleukin 6 (β = -0.40 to -0.68) but not C-reactive protein (β = 0.10 to 0.29) 1 hour after the stressor. CONCLUSIONS: These findings expand on the current literature by showing that changes in HF-HRV predict and precede changes in circulating inflammatory cytokines in humans and may have implications for treatment of inflammatory diseases

Autonomic nervous system · Blood pressure · C-reactive protein · Cytokine · Heart rate · Heart rate variability · Immune system · Inflammation · Interleukin 6 · Psychoneuroimmunology · Reflex · Stressor · Tumor necrosis factor alpha · Vagal tone · Vagus nerve · Clinical Psychology · Endocrinology · Heart Rate Variability and Autonomic Control · Immunology · Internal Medicine · Medicine · Neuroscience of respiration and sleep · Vagus Nerve Stimulation Research

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