Excretion of 17-Hydroxycorticosteroids and Vanillylmandelic Acid During 205 Hours of Sleep Deprivation in Man
Bibliographic Data
| ID | 19308358 |
|---|---|
| Authors | Robert T Rubín (0000-0002-0304-4303, Naval Medical Center San Diego), EDWARD J KOLLAR (Naval Medical Center San Diego), GRANT G SLATER (Naval Medical Center San Diego), Brian R Clark (0000-0001-6611-3807, Naval Medical Center San Diego) |
| Year | 1969 |
| Volume | 31 |
| Issue | 1 |
| Pages | 68-79 |
| Publication date | 1969-01-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/00006842-196901000-00007 |
| PMID | 5775857 |
| OpenAlex | W2330710474 |
| Language | EN |
| Citations received | 1 |
| References cited | 2 |
Previous studies of adrenocortical activity during sleep deprivation revealed unchanged or lowered plasma 17-hydroxycorticosteroid (17-OHCS) levels and either unchanged, lowered, or elevated urine 17-OHCS values, depending on the subject and the length of the deprivation period. In the present study, plasma 17-OHCS, urine 17-OHCS, and urine vanillymandelic acid (VMA) were measured during 205 hr. of wakefulness, the rationale being that an extended period of sleep deprivation might result in more definitive physiological responses. Plasma 17-OHCS in all 4 subjects decreased to a low point at about 90 hr., then increased to peak values at about 170 hr. Urine 17-OHCS values tended to reflect changes in plasma 17-OHCS levels. Urine VMA excretion varied considerably among the 4 subjects. The results suggest that prolonged sleep deprivation per se results in only mild, if any, specific activation of the pituitary-adrenocortical axis and in variable increases of catecholamine biosynthesis. Differing patterns of physiological activity may occur among sleep-deprived subjects
Catecholamine · Circadian rhythm · Electroencephalography · Excretion · Homovanillic acid · Psychiatry · Serotonin · Sleep (system call) · Sleep deprivation · Urine · Vanillylmandelic acid · Wakefulness · Chemistry · Circadian rhythm and melatonin · Endocrinology · Exercise and Physiological Responses · Internal Medicine · Medicine · Psychology · Stress Responses and Cortisol
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,02 |
| Citation span | 1972 - 1972 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |