Increases in Exhaled Nitric Oxide After Acute Stress

Association With Measures of Negative Affect and Depressive Mood

Bibliographic Data

ID19308679
AuthorsThomas Ritz (0000-0003-0461-1039, The University of Texas Southwestern Medical Center, corresponding author), Ana F Trueba (0000-0003-2954-7328), Erica Simon (0000-0002-5221-5738), Richard J Auchus (0000-0001-6815-6181)
Year2014
Volume76
Issue9
Pages716-725
Publication date2014-11-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0000000000000118
PMID25353641
OpenAlexW2088508473
LanguageEN
Citations received2
References cited68

BACKGROUND: Increases in fractional exhaled nitric oxide (FeNO) have been observed after acute laboratory stress, which could indicate a strengthening of immune defenses in acute stress because of the quick onset of the response and the role of nitric oxide in airway-protective functions. In addition, because sustained psychological distress and depression are known to deteriorate immune defenses systems, they may dampen the FeNO response to acute stress. METHODS: FeNO and negative affect were measured before and after a speech and mental arithmetic stressor. We examined the association of stress-induced FeNO changes with momentary negative affect and questionnaires of perceived stress, anxious mood, and depressive mood in 39 asthma patients and 41 healthy controls. RESULTS: FeNO increased from baseline to stress in participants with asthma (from 3.38 [0.102] to 3.46 [0.103] ln(ppb)) and controls (2.86 [0.098] to 2.92 [0.099]; F(4,141) = 3.26, p = .014), but the magnitude of the FeNO response did not differ between groups (F < 1). Only low levels of depressive mood were associated with FeNO increases after stress (most pronounced at 0 minute poststress; t(76) = 3.87, p < .001). In contrast, only higher perceived stress was associated with FeNO increases (most pronounced at 0 minute poststress; t(75) = 4.09, p < .001), and momentary negative affect was associated with higher FeNO throughout assessments (β = 0.08, t(114) = 8.27, p = .005). Associations of FeNO with psychological variables were largely unrelated to asthma status and inhaled corticosteroid use. CONCLUSIONS: Depressive mood is associated with a reduced mobilization of airway nitric oxide in acute stress, whereas other indicators of negative affect are positively associated with overall FeNO levels and reactivity

Affect (linguistics) · Anxiety · Asthma · Depression (economics) · Exhaled nitric oxide · Mood · Nitric oxide · Profile of mood states · Psychiatry · Spirometry · Stressor · Clinical Psychology · Internal Medicine · Medicine · Nitric Oxide and Endothelin Effects · Psychology · Stress Responses and Cortisol · Traditional Chinese Medicine Studies

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