Child Maltreatment and Inflammatory Response to Mental Stress Among Adults Who Have Survived a Myocardial Infarction
Bibliographic Data
| ID | 19309346 |
|---|---|
| Authors | Shakira F Suglia (0000-0002-5634-9290, Emory University, corresponding author), Shakia T Hardy (0000-0001-9211-0474, Emory University), Alison L Cammack (0000-0003-3707-2158, Emory University), Ye Ji Kim (0000-0003-1583-1408, Emory University), Bradley D Pearce (Emory University), Amit Shah (0000-0001-9099-9687, Emory University), Amit J Shah, Samaah Sullivan (0000-0001-9427-7235, Emory University), Matthew T Wittbrodt (0000-0002-9533-8041, Emory University), Matthew Wittbrodt, J Douglas Bremner (0000-0003-1633-6433, Emory University), Viola Vaccarino (0000-0002-9054-0654, Emory University) |
| Year | 2022 |
| Volume | 84 |
| Issue | 9 |
| Pages | 1013-1020 |
| Publication date | 2022-11-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0000000000001114 |
| PMID | 35980788 |
| OpenAlex | W4292246523 |
| Language | EN |
| References cited | 62 |
OBJECTIVE: Experiences of child maltreatment are associated with cardiovascular risk and disease in adulthood; however, the mechanisms underlying these associations are poorly understood. METHODS: We examined associations between retrospectively self-reported exposure to child maltreatment (Early Trauma Inventory Self-Report Short Form) and inflammatory responses to mental stress among adults (mean age = 50 years) who recently had a myocardial infarction ( n = 227). Inflammation was assessed as blood interleukin-6 (IL-6), matrix metalloproteinase-9 (MMP-9), and monocyte chemoattractant protein-1 concentrations, measured before and after a standardized public speaking stress task. We used mixed linear regression models adjusting for cardiovascular disease severity, medication usage, and psychosocial, demographic, and life-style factors. RESULTS: In women, increases in IL-6 levels and MMP-9 levels with stress were smaller in those exposed to sexual abuse, relative to those unexposed (IL-6 geometric mean increases = 1.6 [95% confidence interval {CI} = 1.4-1.9] pg/ml versus 2.1 [95% CI = 1.8-2.4] pg/ml; MMP-9 geometric mean increases = 1.0 [95% CI = 0.9-1.2] ng/ml versus 1.2 [95% CI = 1.1-1.4] ng/ml). No differences were noted for emotional or physical abuse. By contrast in men, individuals exposed to sexual abuse had larger IL-6 responses than those not exposed to abuse. CONCLUSIONS: These findings suggest sex differences in stress response among survivors of a myocardial infarction exposed to abuse early in life. They also underscore the importance of examining sex as an effect modifier of relationships between exposure to early life adversity and inflammatory responses to mental stressors in midlife
Child abuse · Confidence interval · Injury prevention · Myocardial infarction · Poison control · Psychiatry · Psychosocial · Sexual abuse · Child Abuse and Trauma · Clinical Psychology · Internal Medicine · Medicine · Posttraumatic Stress Disorder Research · Stress Responses and Cortisol
Multiple Imputation for Missing Data
Psychometric Properties of the Early Trauma Inventory–Self Report
Greater Cardiovascular Responses to Laboratory Mental Stress Are Associated With Poor Subsequent Cardiovascular Risk Status
Multiple imputation for missing data in epidemiological and clinical research
Childhood trauma and adulthood inflammation
Using the outcome for imputation of missing predictor values was preferred
The Adaptive Calibration Model of stress responsivity
Lest we forget
Sex Differences in Mental Stress–Induced Myocardial Ischemia in Young Survivors of an Acute Myocardial Infarction
Sex Differences in Glucocorticoid Sensitivity of Proinflammatory Cytokine Production After Psychosocial Stress
The Mental Stress Ischemia Prognosis Study
Consistent sex differences in cortisol responses to psychological stress
Cardiovascular Stress Reactivity and Health
Life Events and Acute Cardiovascular Reactions to Mental Stress
Child maltreatment and hypertension in young adulthood
Chronic Exposure to Everyday Discrimination and Coronary Artery Calcification in African-American Women
Objective and subjective experiences of child maltreatment and their relationships with psychopathology
| Citation velocity | historical |
|---|---|
| Highly cited | No |