Urinary cyclic AMP excretion is increased in Macaca fascicularis and Macaca mulatta compared to humans

Bibliographic Data

ID19387489
AuthorsJohn L Stock (University of Massachusetts Chan Medical School, corresponding author), James A Coderre (University of Massachusetts Chan Medical School), James A Simon (0000-0002-6968-5250, Georgetown University)
Year1991
Volume23
Issue3
Pages201-206
Publication date1991-01-01
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Primatology (JOURNAL)
Journal identifiersISSN: 0275-2565 • E-ISSN: 1098-2345
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajp.1350230307
PMID31952403
OpenAlexW2084223476
LanguageEN
References cited12

Changes in parathyroid hormone and its second messenger cyclic AMP have been implicated in the pathogenesis of osteoporosis. Nonhuman primate models have been useful in the study of osteoporosis, but the physiology of mineral metabolism in certain species is different than in humans. We investigated parameters of mineral metabolism in 15 normal adult female cynomolgus and 14 normal adult female rhesus monkeys. In both species, urinary cyclic AMP was increased compared with humans, and the nephrogenous cyclic AMP in the cynomolgus monkeys was also elevated. Despite this, there was no evidence for hyperparathyroidism in either species as evaluated by serum or plasma phosphorus and midregion‐specific and/or aminoterminal‐specific immunoreactive parathyroid hormone. Given the increasing use of nonhuman primates in the study of osteoporosis, understanding basic changes in mineral metabolism is important before pathologic effects of bone loss can be understood

Biology · Bone remodeling · Calcium · Excretion · Hormone · Metabolism · Osteoporosis · Parathyroid hormone · Pathogenesis · Primate · Urinary system · Medicine · Pharmacological Effects and Toxicity Studies · Regulation of Appetite and Obesity · Thyroid Disorders and Treatments · Ecology · Endocrinology · Internal Medicine

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