Bone measurement by enhanced contrast image analysis

Ovariectomized and intact Macaca fascicularis as a model for human postmenopausal osteoporosis

Bibliographic Data

ID8314758
AuthorsE A Bowles, Elizabeth Bowles (Wake Forest University), D S Weaver (Wake Forest University), Frank W Telewski (0000-0001-7957-9841, University of Arizona), Andrew H Wakefield (Wake Forest University), M J Jaffe (Wake Forest University), Lisa C Miller (Wake Forest University)
Year1985
Volume67
Issue2
Pages99-103
Publication date1985-06-01
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.1330670204
PMID4061575
OpenAlexW1987022867
LanguageEN
Citations received4
References cited7

This paper presents an image enhancement and analysis system (DARWIN) based on an inexpensive microcomputer and applies the system to two bone morphometry problems relevant to postmenopausal osteoporosis. Using ovariectomized and intact female Macaca fascicularis as a model, we examined the radiodensity of the sixth lumbar vertebra and the cross‐section area of the right femur. Significantly lower bone density was observed in the vertebral segments of the ovariectomized animals. No significant differences were observed in comparisons of the femoral cross sections. The reduction in radiographic density of the ovariectomized animals' vertebrae is similar to that observed in postmenopausal women, supporting the use of female cynomolgus macaques as models of bone loss in postmenopausal osteoporosis

Bone density · Bone mineral · Estrogen · Femur · Lumbar · Lumbar vertebrae · Osteoporosis · Ovariectomized rat · Postmenopausal osteoporosis · Postmenopausal women · Anatomy · Bone health and osteoporosis research · Bone Metabolism and Diseases · Internal Medicine · Medicine · Morphological variations and asymmetry · Surgery

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