The Effects of Haloperidol on Neuronal Firing in Rats Anterior Cingulate Cortex During Cost-Benefit Decision-Making Tasks
The Effects of Haloperidol on Neuronal Firing in Rats Anterior Cingulate Cortex During Cost-Benefit Decision-Making Tasks
Bibliographic Data
| ID | 19408652 |
|---|---|
| Authors | Shui-Xia YUAN, Hu Xu (0009-0008-3316-8041), Xia Li (0000-0003-3050-8529), Kai Gu (0000-0003-4911-583X), Yang-Fan ZUO, Qin-Qin Lü (0000-0002-5022-8877), Shu-Fen DAI, Ping Yu (0000-0002-7910-9396) |
| Year | 2013 |
| Volume | 44 |
| Issue | 3 |
| Pages | 338-353 |
| Publication date | 2013-04-12 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Acta Psychologica Sinica (JOURNAL) |
| Journal identifiers | ISSN: 0439-755X |
| Publisher | China Science Publishing & Media Ltd (PUBLISHER) |
| DOI | 10.3724/sp.j.1041.2012.00338 |
| OpenAlex | W2751831293 |
| Language | EN |
| References cited | 3 |
摘要: 运用在体多通道神经元放电同步记录技术, 观察和记录大鼠在完成T-迷宫成本效益决策任务时前扣带回神经元放电和局部场电位的变化及氟哌啶醇对此的改变, 在细胞水平上探讨前扣带回在决策中的作用以及多巴胺递质系统对决策的作用机制。结果显示, 经过一段时间的训练, 10只大鼠中有8只偏好高付出-高奖赏端, 且在选择高付出-高奖赏端时的神经元放电频率要显著高于选择低付出-低奖赏端时的频率, 同时局部场电位也呈现出事件相关性; 腹腔注射多巴胺受体拮抗剂氟哌啶醇后, 大鼠不再偏好高付出-高奖赏端, 对该端的选择显著减少, 而对低付出-低奖赏端的选择显著增加, 且神经元的放电频率和局部场电位显著降低, 神经元放电和局部场电位的特征性也消失。研究提示, 前扣带回和多巴胺在努力相关决策任务中有着至关重要的作用
Anterior cingulate cortex · Central nervous system · Cingulate cortex · Cognition · Cognitive psychology · Haloperidol · Anesthesia and Sedative Agents · Neuroscience · Psychology
| Citation velocity | historical |
|---|---|
| Highly cited | No |