Low body mass index and efavirenz use are independently associated with self-reported fatigue in HIV-infected patients

Bibliographic Data

ID19438604
AuthorsKeran Wang (Fudan University), Haijiang Lin (0000-0002-4550-0258, Taizhou City Center for Disease Control and Prevention, Taizhou City of Zhejiang Province, People’s Republic of China), Lingling Li (0000-0002-5951-8387, Fudan University), Qionghai Wu (Taizhou City Center for Disease Control and Prevention, Taizhou City of Zhejiang Province, People’s Republic of China), Weiwei Shen (0000-0002-6893-5158, Taizhou City Center for Disease Control and Prevention, Taizhou City of Zhejiang Province, People’s Republic of China), Xing Liu (0000-0001-8578-3769, Fudan University), Meiyang Gao (Fudan University), Sujuan Zhou (Fudan University), Yingying Ding (0000-0001-6533-8035, Fudan University), Na He (0000-0003-4347-7899, Fudan University, corresponding author)
Year2019
Volume31
Issue4
Pages513-518
Publication date2019-04-03
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2018.1524110
PMID30246544
OpenAlexW2893748780
LanguageEN
Citations received1
References cited39

This retrospective cohort study was conducted from January 2009 to July 2016 to explore the occurrence and risk factors of self-reported fatigue within the first 6 months after receiving antiretroviral treatment (ART) among patients living with HIV in Taizhou City of Zhejiang province, Eastern China. In total, 1163 HIV-infected patients with a median follow-up duration of 27.8 months were included in the analysis. Among them, 261 (22.4%) reported fatigue within the first 6 months after ART. In the multivariable logistic regression analysis, self-reported fatigue within the first 6 months after ART was negatively associated with junior middle-school education or above, baseline CD4 cell count of 200-349 and >350 cells/μL (vs < 200 cells/μL), overweight at baseline (vs normal weight) but positively associated with ≥50 years old at initiation of ART (vs <30 years old), underweight at baseline, use of efavirenz (EFV) in the first-line regimen. Our data suggest that earlier initiation of ART and higher body mass index are preferred to restore the energy of HIV-infected patients with the EFV use in the era of ART in China

Antiretroviral therapy · Body mass index · Cohort · Cohort study · Efavirenz · Logistic regression · Overweight · Regimen · Retrospective cohort study · Underweight · Viral load · Demography · HIV-related health complications and treatments · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Immunology · Internal Medicine · Pediatrics

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