Point-of-care viral load testing among adolescents and young adults living with HIV in Haiti

A randomized control trial

Bibliographic Data

ID19438836
AuthorsLindsey K Reif (0000-0003-3427-4475, Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA, corresponding author), Marie Elmase Belizaire (GHESKIO Center, Port-au-Prince, Haiti), Vanessa Rouzier (0000-0002-9672-9474, Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA), Grace Seo (0000-0002-6503-7192, Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA), Patrice Sévère (GHESKIO Center, Port-au-Prince, Haiti), Joseph-Marie Bajo Joseph (GHESKIO Center, Port-au-Prince, Haiti), Bernadette Joseph (GHESKIO Center, Port-au-Prince, Haiti), Sandra Apollon (GHESKIO Center, Port-au-Prince, Haiti), Jean W Pape (0000-0002-2948-2774, Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA), Margaret L McNairy (0000-0001-7853-633X, Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA), Batya Elul (0000-0001-6101-3073, Columbia University), Daniel W Fitzgerald (0000-0003-1765-0598, Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, USA), Stephen M Arpadi (0000-0002-9129-2912, ICAP at Columbia University, Mailman School of Public Health, Columbia University, NY, USA), Elaine J Abrams (0000-0001-7938-8981, ICAP at Columbia University, Mailman School of Public Health, Columbia University, NY, USA), Louise Kuhn (0000-0002-2305-8665, Columbia University)
Year2022
Volume34
Issue4
Pages409-420
Publication date2022-04-03
Open AccessYes
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2021.1981816
PMID34612092
OpenAlexW3204428373
LanguageEN
Citations received1
References cited31

HIV viral load (VL) monitoring can reinforce antiretroviral therapy (ART) adherence. Standard VL testing requires high laboratory capacity and coordination between clinic and laboratory which can delay results. A randomized trial comparing point-of-care (POC) VL testing to standard VL testing among 150 adolescents and young adults, ages 10-24 years, living with HIV in Haiti determined if POC VL testing could return faster results and improve ART adherence and viral suppression. Participants received a POC VL test with same-day result (POC arm) or a standard VL test with result given 1 month later (SOC arm). POC arm participants were more likely to receive a test result within 6 weeks than SOC arm participants (94.7% vs. 80.1%; p1000 copies/ml and low self-reported ART adherence was stronger in the POC arm (OR: 6.57; 95%CI: 2.12-25.21) than the SOC arm (OR: 2.62; 95%CI: 0.97-7.44) suggesting more accurate self-report in the POC arm. POC VL testing was effectively implemented in this low-resource setting with faster results and is a pragmatic intervention that may enable clinicians to identify those with high VL to provide enhanced counseling or regimen changes sooner.Trial registration: ClinicalTrials.gov identifier: NCT03288246

Clinical endpoint · Family medicine · Physical therapy · Point of care · Point-of-care testing · Randomized controlled trial · Regimen · Viral load · HIV Research and Treatment · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Nursing · Immunology · Internal Medicine

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