Predictors of isoniazid preventive therapy completion among HIV-infected patients receiving differentiated and non-differentiated HIV care in rural Uganda

Bibliographic Data

ID19440300
AuthorsKhai Hoan Tram (0000-0003-1129-7674, Stanford University), Florence Mwangwa (0000-0001-9467-0950, Infectious Diseases Research Collaboration, Kampala, Uganda), Gabriel Chamie (0000-0002-5860-8081, Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA), Mucunguzi Atukunda (0000-0003-4762-0728, Infectious Diseases Research Collaboration, Kampala, Uganda), Asiphas Owaraganise (0000-0002-5594-0310, Infectious Diseases Research Collaboration, Kampala, Uganda), James Ayieko (0000-0002-0324-4006, Kenya Medical Research Institute, Nairobi, Kenya), Vivek Jain (0000-0002-3331-1142, Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA), Tamara D Clark (0000-0003-1109-6039, Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA), Dalsone Kwarisiima (0000-0003-2886-9261, Infectious Diseases Research Collaboration, Kampala, Uganda), Maya L Petersen (0000-0002-5505-153X, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda), Moses R Kamya (0000-0001-9106-4234, Infectious Diseases Research Collaboration, Kampala, Uganda), Edwin D Charlebois (0000-0001-7237-2119, Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA), Diane V Havlir (0000-0003-0761-3136, Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA), Carina Marquez (0000-0002-7622-6562, Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA, corresponding author), the SEARCH collaboration the SEARCH collaboration (Stanford University), the SEARCH Collaboration (Stanford University)
Year2020
Volume32
Issue1
Pages119-127
Publication date2020-01-02
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2019.1619661
PMID31181961
OpenAlexW2953124419
LanguageEN
Citations received3
References cited25

Rates of Isoniazid Preventive Therapy (IPT) completion remain low in programmatic settings in sub-Saharan Africa. Differentiated HIV care models may improve IPT completion by addressing joint barriers to IPT and HIV treatment. However, the impact of differentiated care on IPT completion remains unknown. In a cross-sectional study of people with HIV on antiretroviral therapy in 5 communities in rural Uganda, we compared IPT completion between patients receiving HIV care via a differentiated care model versus a standard HIV care model and assessed multi-level predictors of IPT completion. A total of 103/144 (72%) patients received differentiated care and 85/161 (53%) received standard care completed IPT (p < 0.01). Adjusting for age, gender and community, patients receiving differentiated care had higher odds of completing IPT (aOR: 2.6, 95% CI: 1.5–4.5, p < 0.01). Predictors of IPT completion varied by the care model, and differentiated care modified the positive association between treatment completion and the belief in the efficacy of IPT and the negative association with side-effects. Patients receiving a multi-component differentiated care model had a higher odds of IPT completion than standard care, and the model’s impact on health beliefs, social support, and perceived side effects to IPT may underlie this positive association

Family medicine · Health care · Logistic regression · Odds · Odds ratio · Physical therapy · Global Maternal and Child Health · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Internal Medicine

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