Alcohol use as a mediator of the effect of two alcohol reduction interventions on mental health symptoms of ART clients in Vietnam

Bibliographic Data

ID19440879
AuthorsM X Nguyen (0000-0002-9487-5654, University of North Carolina at Chapel Hill, corresponding author), H Luz Mcnaughton Reyes (0000-0002-8696-9140, University of North Carolina at Chapel Hill), Brian W Pence (0000-0001-7321-9538, University of North Carolina at Chapel Hill), K Muessig (University of North Carolina at Chapel Hill), K E Muessig (University of North Carolina at Chapel Hill), Heidi E Hutton (0000-0002-0882-4456, Johns Hopkins University), H Hutton (Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA), Carl Latkin (0000-0002-7931-2116, Johns Hopkins University), C A Latkin (Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA), David Dowdy (0000-0003-0481-7475, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA), G Chander (0000-0002-2216-6330, Johns Hopkins University), Kathryn E Lancaster (0000-0003-2389-6973, The Ohio State University), Constantine Frangakis (0000-0002-6932-0614, Johns Hopkins University), Teerada Sripaipan (University of North Carolina at Chapel Hill), Tran Viet Ha (0000-0002-8549-4761, University of North Carolina at Chapel Hill), H V Tran (University of North Carolina at Chapel Hill), Vivian F Go (0000-0003-4828-6880, University of North Carolina at Chapel Hill)
Year2023
Volume35
Issue11
Pages1691-1699
Publication date2023-11-02
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2023.2183378
PMID36912652
OpenAlexW4324020363
LanguageEN
References cited44

We aimed to examine the mediating role of alcohol use in the pathway from the interventions to depression and anxiety symptoms using data from a randomized controlled trial among people living with HIV (PWH) with hazardous alcohol use (n = 440) in Thai Nguyen, Vietnam. Participants were randomized into either a combined intervention (CoI), a brief intervention (BI) and a standard of care arm. Both interventions were based on cognitive behavioral therapy and motivational enhancement therapy. Alcohol use was measured as the percentage of days abstinent from alcohol in the last 30 days. Symptoms of depression and anxiety were measured with the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 scales. Alcohol use was a significant mediator of the effects of two alcohol interventions on depression symptoms, but not anxiety symptoms. There were significant indirect effects via alcohol use of both interventions on depression symptoms at 12 months (CoI: mean difference (MD) = −0.134; 95%CI: −0.251, −0.035); (BI: MD = −0.141; 95%CI: −0.261, −0.038). There were no significant direct or total effects of the interventions on either symptoms at 12 months. Interventions with a dual focus on mental health and alcohol disorders are needed to determine optimal ways to tackle these common comorbidities among PWH

Alcohol · Alcohol dependence · Alcohol use disorder · Anxiety · Brief intervention · Mental health · Psychiatry · Psychological intervention · Randomized controlled trial · Clinical Psychology · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Substance Abuse Treatment and Outcomes · Internal Medicine

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