Correlation between computerised and standard cognitive testing in people with HIV and HIV-negative individuals

Bibliographic Data

ID19441887
AuthorsDavide De Francesco (0000-0002-6185-0514, Institute for Global Health, University College London, London, UK), Jonathan Underwood (0000-0001-6963-2821, Imperial College London), Jane Anderson (0000-0001-5294-8707, Homerton University Hospital, London, UK), Marta Boffito (0000-0002-2213-1103, Chelsea and Westminster Healthcare NHS Foundation Trust, London, UK), Frank A Post (0000-0002-2844-1612, King's College Hospital NHS Foundation Trust, London, UK), Memory Sachikonye (0000-0002-0408-1456, UK Community Advisory Board, London, UK), Patrick Mallon (0000-0002-4337-6222, University College Dublin), Patrick W G Mallon (University College Dublin School of Medicine, Dublin, Ireland), Lewis Haddow (0000-0003-3016-2986, Institute for Global Health, University College London, London, UK), Jaime H Vera (0000-0002-1165-0573, Brighton and Sussex Medical School, Brighton, UK), Ken M Kunisaki (0000-0001-8644-2827, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA), Caroline Sabin (0000-0001-5173-2760, Institute for Global Health, University College London, London, UK, corresponding author), Alan Winston (0000-0002-5847-8416, Imperial College London)
Year2021
Volume33
Issue10
Pages1296-1307
Publication date2021-10-03
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2020.1865518
PMID33356492
OpenAlexW3113630772
LanguageEN
References cited33

We investigated the correlations and agreement between cognitive assessments made using a computerised (CogStateTM, six domains) and a standard pen-and-paper battery (five domains) in PWH and lifestyle-similar HIV-negative individuals. Demographically adjusted domain and global T-scores were obtained and used to define cognitive impairment according to the multivariate normative comparison (MNC) criteria. Correlations between T-scores and the agreement between the classifications of cognitive impairment obtained from the two batteries were assessed using the Spearman’s rank correlation and Cohen’s κ, respectively. The correlation between global T-scores from the two batteries was 0.52 (95% CI 0.44–0.60) in PWH and 0.45 (0.29–0.59) in controls (p = 0.38 for their difference). Correlations were generally stronger between domains within the same battery than between those from different batteries. The agreement between the two batteries in classifying individuals as cognitively impaired or not impaired was fair in PWH (κ = 0.24) and poor in HIV-negative individuals (κ = −0.02). The moderate correlation between overall cognitive function and the modest agreement between binary classifications of cognitive impairment obtained from two different batteries indicate the two batteries may assess slightly different components of cognition

Audiology · Cognition · Cognitive impairment · Cognitive test · Correlation · Multivariate analysis · Normative · Psychiatry · Rank correlation · Spearman's rank correlation coefficient · Statistics · Clinical Psychology · HIV Research and Treatment · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Mathematics · Medicine · Psychology · Immunology · Internal Medicine

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