Menstrual cycle phase and single tablet antiretroviral medication adherence in women with HIV

Bibliographic Data

ID19444044
AuthorsNancy A Hessol (0000-0003-3374-8384, University of California, San Francisco, corresponding author), Susan Holman (SUNY Downstate Health Sciences University), Howard Minkoff (0000-0002-7800-7195, Maimonides Medical Center), Marsha H Cohen (0000-0002-1351-9624, Rush University), Mardge H Cohen, Elizabeth T Golub (0000-0001-5860-4913, Johns Hopkins University), Seble Kassaye (0000-0002-7527-7384, Georgetown University), Roksana Karim (0000-0003-1761-153X, University of Southern California), Oluwakemi Sosanya (0000-0003-4514-297X, Montefiore Medical Center), Christopher Shaheen, Chanda Shaheen (University of California, San Francisco), Zaher Merhi (0000-0002-7952-1428, New York University)
Year2016
Volume28
Issue1
Pages11-21
Publication date2016-01-02
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2015.1069787
PMID26274806
OpenAlexW1507003444
LanguageEN
References cited32

Suboptimal adherence to antiretroviral (ARV) therapy among HIV-infected individuals is associated with increased risk of progression to AIDS and the development of HIV resistance to ARV medications. To examine whether the luteal phase of the menstrual cycle is independently associated with suboptimal adherence to single tablet regimen (STR) ARV medication, data were analyzed from a multicenter cohort study of HIV-infected women who reported regular menstrual cycles and were taking an STR. In a cross-sectional analysis, suboptimal adherence to an STR among women in their follicular phase was compared with suboptimal adherence among women in their luteal phase. In two-way crossover analyses, whereby the same woman was assessed for STR medication adherence in both her follicular and luteal phases, the estimated exact conditional odds of non-adherence to an STR was measured. In adjusted logistic regression analysis of the cross-sectional data (N=327), women with ≤12 years of education were more than three times more likely to have suboptimal adherence (OR=3.6, p=.04) compared to those with >12 years of education. Additionally, women with Center for Epidemiological Studies Depression Scale (CES-D) scores ≥23 were 2.5-times more likely to have suboptimal adherence (OR=2.6, p=.02) compared to those with CES-D scores <23. In conditional logistic regression analyses of the crossover data (N=184), having childcare responsibilities was associated with greater odds of ≤95% adherence. Menstrual cycle phase was not associated with STR adherence in either the cross-sectional or crossover analyses. The lack of association between phase of the menstrual cycle and adherence to an STR in HIV-infected women means attention can be given to other more important risk factors for suboptimal adherence, such as depression, level of education, and childcare responsibilities

Cohort · Cross-sectional study · Crossover study · Follicular phase · Logistic regression · Luteal phase · Menstrual cycle · Obstetrics · Odds · Odds ratio · Regimen · Adolescent Sexual and Reproductive Health · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Medicine · Internal Medicine

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