Intergenerational influences on diabetes in a developing population

The Guangzhou Biobank Cohort Study

Bibliographic Data

ID19458676
AuthorsKavikondala (0000-0002-3615-0102, University of Hong Kong), S Kavikondala, C Q Jiang (0000-0001-6589-1068, Twelfth Guangzhou City People's Hospital), W S Zhang (Twelfth Guangzhou City People's Hospital), K K Cheng (0000-0002-1516-1857, University of Birmingham), Th Lam (0000-0002-2033-9971, University of Hong Kong), T H Lam, Genevieve Leung (0000-0002-2503-6283, University of Hong Kong), G M Leung, C Mary Schooling (0000-0001-9933-5887, University of Hong Kong, corresponding author)
Year2011
Volume23
Issue6
Pages747-754
Publication date2011-11-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Human Biology (JOURNAL)
Journal identifiersISSN: 1042-0533 • E-ISSN: 1520-6300
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajhb.21206
PMID21987430
OpenAlexW2059775785
LanguageEN
Citations received2
References cited39

OBJECTIVES: Intergenerational "mismatch" and/or growth conditions may be relevant to the epidemic of diabetes in developing populations. In a rapidly developing southern Chinese population, we tested whether maternal environment, proxied by maternal literacy, or family socio-economic position (SEP), proxied by paternal literacy, were associated with fasting glucose and diabetes. To assess if intergenerational mismatch contributed, we tested whether the associations varied by life course SEP. METHODS: In 19,818 older (≥50 years) adults from the Guangzhou Biobank Cohort Study (phases 2 and 3), we used censored and logistic regression to assess the associations of maternal and paternal literacy with fasting glucose, elevated fasting glucose and diabetes and whether these associations varied by sex, age or life course SEP. RESULTS: Maternal, but not paternal, literacy was negatively associated with fasting plasma glucose (β-coefficient -0.06 mmol/l, 95% confidence interval (CI) -0.11 to -0.01) and elevated fasting glucose (odds ratio (OR) 0.92, 95% CI 0.86-0.99) adjusted for age, sex, study phase, life course SEP, childhood growth, adiposity, number of offspring, and birth order. Associations of maternal and paternal literacy with fasting glucose, elevated fasting glucose and diabetes did not vary by sex, age or life course SEP. CONCLUSION: Offspring of literate mothers had lower risk for impaired glucose tolerance than offspring of illiterate mothers. Being raised by literate mothers may increase the likelihood of children with higher SEP and lower long-term disease risk, or better maternal conditions over generations may be associated with lower fasting glucose

Biology · Cohort · Cohort study · Confidence interval · Developmental psychology · Diabetes mellitus · Environmental health · Impaired fasting glucose · Impaired glucose tolerance · Life course approach · Logistic regression · Odds ratio · Offspring · Population · Prediabetes · Pregnancy · Type 2 diabetes · Birth, Development, and Health · Demography · Diabetes, Cardiovascular Risks, and Lipoproteins · Health Literacy and Information Accessibility · Medicine · Psychology · Endocrinology · Gerontology · Internal Medicine

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