Epstein‐Barr virus antibody titer and its association with the domain scores from the World Health Organization's Quality of Life questionnaire

Findings from Rural Hainan Province, China

Bibliographic Data

ID19458741
AuthorsYosuke Inoue (0000-0002-7690-3447, Department of Human Ecology, Graduate School of Medicine The University of Tokyo Tokyo 113‐0033 Japan, corresponding author), Aki Yazawa (0000-0002-4335-3880, Department of Human Ecology, Graduate School of Medicine The University of Tokyo Tokyo 113‐0033 Japan), Dandan Li (0000-0002-5735-4681, Hainan Provincial Center for Disease Control and Prevention Japan), Jianwei Du (Hainan Provincial Center for Disease Control and Prevention Japan), Yuming Jin (0000-0003-3632-6697, Hainan Provincial Center for Disease Control and Prevention Japan), Yan Chen (0000-0003-4119-9688, Hainan Provincial Center for Disease Control and Prevention Japan), Chiho Watanabe (0000-0002-2114-3903, Department of Human Ecology, Graduate School of Medicine The University of Tokyo Tokyo 113‐0033 Japan), Masahiro Umezaki (0000-0003-3733-3629, Department of Human Ecology, Graduate School of Medicine The University of Tokyo Tokyo 113‐0033 Japan)
Year2014
Volume26
Issue1
Pages51-55
Publication date2014-01-01
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Human Biology (JOURNAL)
Journal identifiersISSN: 1042-0533 • E-ISSN: 1520-6300
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajhb.22478
PMID24327424
OpenAlexW1900230122
LanguageEN
Citations received8
References cited26

OBJECTIVE: Epstein-Barr virus (EBV) antibody titer has recently been used as a biomarker of psychological stress. This is the first study to investigate the association between EBV antibody titer and perceived quality of life (QOL) in Hainan Island, China. METHODS: Participants from two regions of Hainan Island, recruited into a larger study investigating the health impact of rapid economic development among rural residents, were stratified by age, sex, and region; 15 people were randomly selected from each of the 16 subgroups, to give a total sample size of 240. EBV antibody titer in dried blood spot samples was measured by enzyme-linked immunosorbent assay. The abbreviated version of the World Health Organization's Quality of Life questionnaire was used to gather information on six categories of QOL. Multiple linear regression analysis was used to examine the relationship between EBV antibody titer and QOL. RESULTS: After adjusting for the effects of age, sex, region and C-reactive protein concentration, EBV antibody titer was negatively associated with the physical (P = 0.044) and psychological QOL domains (P = 0.039). CONCLUSION: This study suggests that among individuals living in an environment in the initial stages of economic development EBV antibody titer, a biomarker of psychological stress, is not only associated with the psychological aspects of QOL but is also linked to physical problems

Antibody · Antibody titer · Biology · Biomarker · China · Geography · Titer · Cancer survivorship and care · Demography · Medicine · Stress Responses and Cortisol · Viral-associated cancers and disorders · Gerontology · Immunology

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