Circumpolar adaptation, social change, and the development of autoimmune thyroid disorders among the Yakut (Sakha) of Siberia
Bibliographic Data
| ID | 19458956 |
|---|---|
| Authors | Tara J Cepon (University of Oregon, corresponding author), Jeffrey Snodgra (0000-0002-7021-777X, University of Oregon), W R Leonard (0000-0002-6233-604X, Northwestern University), Larissa A Tarskaia (University of Kansas), Tatiana M Klimova (0000-0003-2746-0608), Valentina I Fedorova (0000-0002-6147-4643), Marina E Baltakhinova (0000-0003-0986-7754), Vadim G Krivoshapkin |
| Year | 2011 |
| Volume | 23 |
| Issue | 5 |
| Pages | 703-709 |
| Publication date | 2011-09-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 1042-0533 • E-ISSN: 1520-6300 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajhb.21200 |
| PMID | 21732471 |
| OpenAlex | W2130338301 |
| Language | EN |
| Citations received | 16 |
| References cited | 39 |
OBJECTIVES: Alterations in thyroid function appear to play a central role in adaptation to Arctic environments. Increased thyroid activity in indigenous circumpolar populations is associated with upregulated metabolism, including elevated basal metabolic rate (BMR); however, little is known about the possible health consequences of these climate-induced changes on thyroid function. The focus of the present study is to determine the prevalence of autoimmune thyroid disorders and their lifestyle and metabolic correlates among a sample of indigenous Yakut adults from northeastern Siberia. METHODS: Anthropometric dimensions, health data, and plasma samples were collected among 281 adults (143 women, 138 men; ≥18 years old) from the rural community of Berdygestiakh (62°N, 127°E; pop. 4,900), Sakha Republic (Yakutia), Russia. BMR measurements were available for 96 women and 98 men. Free triiodothyronine (T(3) ), free thyroxine (T(4) ), thyroid stimulating hormone (TSH), and anti-thyroid peroxidase antibody (TPOAb) levels were determined using enzyme immunoassay. RESULTS: Twenty-two percent of women and 6% of men had clinically elevated (>30 IU/ml) TPOAb. TPOAb was positively correlated with TSH (P < 0.01), T(3) (P < 0.05), and T(4) (P < 0.05) in women and showed a positive trend with T(4) (P = 0.06) in men. Monthly household income was significantly positively correlated with TPOAb in men (P < 0.01) and showed a trend among women (P = 0.06). CONCLUSIONS: Although preliminary, these findings document higher than expected TPOAb levels among Yakut women and suggest possible consequences of increased thyroid activity associated with circumpolar adaptation and social change
Anthropometry · Circumpolar star · Deiodinase · Euthyroid · Free thyroxine · Thyroid · Thyroid function · Thyroid peroxidase · Triiodothyronine · Birth, Development, and Health · Demography · Indigenous Studies and Ecology · Medicine · Thyroid Disorders and Treatments · Endocrinology · Internal Medicine · Physiology
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| Unique citing works | 16 |
|---|---|
| Citations per year | 1,23 |
| Citation span | 2013 - 2026 (14) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 16 |