Involvement of low- and middle-income countries in randomized controlled trial publications in oncology
Bibliographic Data
| ID | 19533926 |
|---|---|
| Authors | Janice Wong (0000-0002-4407-9182, Brigham and Women's Hospital), Janice C Wong, Kimberly A Fernandes (0000-0002-1030-9162, Institute for Clinical Evaluative Sciences), Shubarna Amin (Canada Research Chairs), Zarnie Lwin (0009-0006-5009-4895, Royal Brisbane and Women's Hospital), Monika K Krzyzanowska (0000-0001-5533-7418, Canada Research Chairs, corresponding author) |
| Year | 2014 |
| Volume | 10 |
| Issue | 1 |
| Pages | 83-83 |
| Publication date | 2014-12-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Globalization and Health (JOURNAL) |
| Journal identifiers | ISSN: 1744-8603 • E-ISSN: 1744-8603 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1186/s12992-014-0083-7 |
| PMID | 25498958 |
| PMCID | PMC4273324 |
| OpenAlex | W2113292183 |
| Language | EN |
| Citations received | 1 |
| References cited | 27 |
BACKGROUND: We describe trends in participation by investigators from low- and middle-income countries (LMCs) in publications describing oncology randomized control trials (RCTs) over a decade. METHODS: We used Medline to identify RCTs published in English from 1998 to 2008 evaluating treatment in lung, breast, colorectal, stomach and liver cancers. Data on author affiliations, authorship roles, trial characteristics, funding and interventions were extracted from each article. Countries were stratified as low-, middle- or high-income using World Bank data. Interventions were categorized as requiring basic, limited, enhanced or maximal resources as per the Breast Health Global Initiative classification. Logistic regression was used to identify factors associated with authorship by investigators from LMCs. RESULTS: 454 publications were identified. Proportion of articles with at least one LMC author increased over time from 20% in 1998 to 29% in 2008 (p = 0.01), but almost all LMC authors were from middle-income countries. Proportion of articles with at least one LMC author was higher among articles that explicitly reported recruitment in at least one LMC vs those that did not (76% vs 13%). Among 87 articles (19%) that involved authors from LMCs, 17% had LMC authors as first or corresponding authors, and 67% evaluated interventions requiring enhanced or maximal resources. Factors associated with LMC authorship included industry funding (OR = 3.54, p = 0.0001), placebo comparator arm (OR = 2.57, p = 0.02) and palliative intent treatment (OR = 4.00, p = 0.0003). CONCLUSION: An increasing number of publications describing oncology RCTs involve authors from LMC countries but primarily in non-leadership roles in industry-funded trials
Family medicine · Health services research · MEDLINE · Political science · Psychological intervention · Public health · Randomized controlled trial · Ethics in Clinical Research · Medicine · Meta-analysis and systematic reviews · Nursing · Pharmaceutical industry and healthcare · Internal Medicine · Oncology
| Citations per year | 1 |
|---|---|
| Citation span | 2025 - 2025 (1) |
| Highly cited | No |