Long-term survival benefit of male and multimorbid Covid-19 patients with 5-day remdesivir treatment
Bibliographic Data
| ID | 19550432 |
|---|---|
| Authors | Lorinc Polivka (0009-0004-9576-2776, Semmelweis University), Jozsef Gajdacsi (Semmelweis University), Levente Fazekas (0009-0005-0414-6300, Semmelweis University), Szilvia Sebok (Semmelweis University), Eniko Barczi (0000-0001-9644-4172, Semmelweis University), Edit Hidvegi (Semmelweis University), Zoltan Sutto (0000-0002-6871-0901, Semmelweis University), Elek Dinya (Semmelweis University), Pal Maurovich-Horvat, Pál Maurovich‐Horvat (0000-0003-0885-736X, Semmelweis University), Attila J Szabó (0000-0001-7321-9861, Semmelweis University), Bela Merkely (0000-0001-6514-0723, Semmelweis University), Veronika Müller (0000-0002-1398-3187, Semmelweis University, corresponding author) |
| Year | 2022 |
| Volume | 12 |
| Pages | 05031-05031 |
| Publication date | 2022-08-31 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Global Health (JOURNAL) |
| Journal identifiers | ISSN: 2047-2978 • E-ISSN: 2047-2986 |
| Publisher | International Global Health Society (PUBLISHER) |
| DOI | 10.7189/jogh.12.05031 |
| PMID | 36040909 |
| OpenAlex | W4293578890 |
| Language | EN |
| Citations received | 1 |
| References cited | 19 |
Background: Treatment of the coronavirus disease (COVID-19) is still challenging due to the lack of evidence-based treatment protocols and continuously changing epidemiological situations and vaccinations. Remdesivir (RDV) is among the few antiviral medications with confirmed efficacy for specific patient groups. However, real-world data on long-term outcomes for a short treatment course are scarce. Methods: This retrospective observational cohort study included real-life data collected during the second and third wave of the COVID-19 pandemic in Hungary (September 1, 2020-April 30, 2021) from inpatients at a University Center (n = 947). Participants consisted of two propensity score-matched cohorts (370/370 cases): Group RDV including patients receiving RDV and supplementary oxygen and Group standard of care (SOC) as control. The primary outcome was the effect of 5-day RDV treatment on 30- and 60-day all-cause mortality. Multivariate analyses were performed to assess the effect of RDV by different covariates. Results: Group RDV included significantly more patients from the alpha variant wave, with greater frequency of comorbidities diabetes and anemia, and larger degree of parenchymal involvement. All-cause mortality at 30- and 60-day were significantly lower in Group RDV compared to Group SOC. Significant risk reduction of 60-day all-cause mortality was observed for RDV treatment in men and patients with COPD or multiple comorbidities. Conclusions: Hospitalized COVID-19 patients with 5-day RDV treatment had significantly lower 30- and 60-day all-cause mortality, despite their more severe clinical condition. Men and patients with multiple comorbidities, including COPD, profited the most from RDV treatment in the long term. Due to the ongoing COVID-19 pandemic, effective treatment regimens are needed for hospitalized patients
Cohort study · Comorbidity · COPD · Diabetes mellitus · Propensity score matching · Retrospective cohort study · COVID-19 Clinical Research Studies · Medicine · Pharmacological Receptor Mechanisms and Effects · SARS-CoV-2 and COVID-19 Research · Epidemiology · Internal Medicine
| Citations per year | 1 |
|---|---|
| Citation span | 2026 - 2026 (1) |
| Highly cited | No |