Respiratory viruses associated with severe acute respiratory infection in children aged <5 years at a tertiary care hospital in Delhi, India during 2013–15

Bibliographic Data

ID19550528
AuthorsSatinder Aneja (0000-0001-9635-8792, Lady Hardinge Medical College), Varinder Singh (0000-0003-1794-174X, Lady Hardinge Medical College), Venkatesh V Narayan (0000-0001-7529-7804, National Center for Disease Control), Mayuri Gohain (All India Institute of Medical Sciences), Avinash Choudekar (0000-0002-0427-7301, All India Institute of Medical Sciences), Bharti Gaur (0000-0003-0503-8625, All India Institute of Medical Sciences), Katherine Roguski DeBord (US Centers for Disease Control and Prevention, Atlanta, Georgia, USA), Katherine Roguski (0000-0001-7711-9067, Centers for Disease Control and Prevention), Brett Whitaker (Centers for Disease Control and Prevention), Anand Krishnan (0000-0002-9173-7811, All India Institute of Medical Sciences), Shobha Broor (0000-0001-9679-4180, All India Institute of Medical Sciences), Siddhartha Saha (0000-0002-7494-267X, National Center for Disease Control), A Danielle Iuliano (0000-0001-8742-3687, Centers for Disease Control and Prevention)
Year2024
Volume14
Pages04230-04230
Publication date2024-11-08
Open AccessYes
TypeARTICLE
VenueJournal of Global Health (JOURNAL)
Journal identifiersISSN: 2047-2978 • E-ISSN: 2047-2986
PublisherInternational Society of Global Health (PUBLISHER • GB)
DOI10.7189/jogh.14.04230
PMID39513276
OpenAlexW4404190568
LanguageEN
References cited49

Background: With the increased availability of licensed vaccines for respiratory viruses such as severe acute respiratory syndrome coronavirus 2, respiratory syncytial virus (RSV), and influenza virus, a better understanding of the viral aetiology of severe acute respiratory infections (SARI) among children could help in optimising the use of these vaccines. We conducted a study among children aged <5 years hospitalised with SARI at a tertiary care children's hospital in north India and tested for common respiratory pathogens. Methods: ) or Fisher exact test (P < 0.05). We used logistic regression to estimate adjusted odds ratios (aORs) which were then used to calculate aetiologic fractions (EFs). Results: We enrolled 840 cases and 419 outpatient controls. Almost half of the individuals in the whole sample were aged <6 months (n = 521, 41.4%). Females made up 33.7% of cases and 37.2% of controls. Viral detections were more common among cases (69%, 95% confidence interval (CI) = 66, 73) compared to controls (33%; 95% CI = 29, 38) (P < 0.01). RSV (n = 257, 31%; 95% CI = 28, 34%) was the most common virus detected among cases. Influenza A was detected among 24 (3%; 95% CI = 2, 4%), and influenza B among 5 (1%; 95% CI = 0, 1%) cases. The association between the virus and SARI was strongest for RSV (aOR = 23; 95% CI = 12, 47; EF = 96%). Antivirals were administered to 1% of SARI cases while 78% received antibiotics. Conclusions: Using a multi-pathogen molecular detection method, we detected respiratory viruses among more than two-thirds of children aged <5 years admitted with SARI in the Delhi tertiary care children's hospital. The guidelines for preventing and managing SARI cases among children could be optimised further with the improved availability of antivirals and vaccines

New delhi · Pathology · Respiratory infection · Respiratory system · Tertiary care · Influenza Virus Research Studies · Medicine · Pneumonia and Respiratory Infections · Respiratory viral infections research · Internal Medicine · Pediatrics

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