Absence of a causal link between Covid-19 and deep vein thrombosis

Insights from a bi-directional Mendelian randomisation study

Bibliographic Data

ID19550662
AuthorsMingxuan Li (0009-0000-3564-0727, Fudan University), Lei Xiao (0000-0002-4473-866X, Fudan University), Jiasheng Cai (0000-0001-7417-6728, Fudan University), Kewei Jiang (0000-0002-6706-4741, Fudan University), Yanglei Li (Fudan University), Siqi Li (0009-0005-6425-1233, Fudan University), Qinyue Wang (Fudan University), Wei Wang (0000-0001-5806-2368, Fudan University), Kailei Shi (0009-0008-2885-8224, Fudan University), Haibo Liu (0000-0002-8555-8569, Fudan University)
Year2024
Volume14
Pages05001-05001
Publication date2024-01-12
Open AccessYes
TypeARTICLE
VenueJournal of Global Health (JOURNAL)
Journal identifiersISSN: 2047-2978 • E-ISSN: 2047-2986
PublisherInternational Society of Global Health (PUBLISHER • GB)
DOI10.7189/jogh.14.05001
PMID38214889
OpenAlexW4390794117
LanguageEN
References cited51

Background: Several large-scale observational studies have found deep vein thrombosis (DVT) to be related with coronavirus disease 2019 (COVID-19). However, whether there is a clear causal connection between the two is unknown. Methods: Our primary analytical method was the inverse variance-weighted (IVW) approach, complemented by the Mendelian randomisation-Egger (MR-Egger) and weighted median methods. We also used MR-Egger to examine the presence of pleiotropy and the Mendelian randomisation pleiotropy residual sum and outlier (MR-PRESSO) approach to analyse for heterogeneity in the data. Results: We did not observe a direct causal relationship between COVID-19 susceptibility (odds ratio (OR) = 1.023; 95% confidence interval (CI) = 0.828-1.264, standard error (SE) = 0.108, P = 0.833), hospitalisation (OR = 1.030; 95% CI = 0.943-1.125, SE = 0.374, P = 0.720), severity (OR = 0.994; 95% CI = 0.923-1.071, SE = 0.038, P = 0.877), and DVT. The results of the reverse Mendelian randomisation (MR) for DVT and COVID-19 susceptibility exhibited heterogeneity and horizontal pleiotropy. Even after removing outliers, we detected no direct causal relationship between the two (OR = 1.015; 95% CI = 0.954-1.080, SE = 0.032, P = 0.630). Similarly, we found no direct causal relationship between DVT and COVID-19 hospitalisation (OR = 0.999; 95% CI = 0.907-1.102, SE = 0.050, P = 0.999) or severity (OR = 1.014; 95% CI = 0.893-1.153, SE = 0.065, P = 0.826). Conclusions: In this MR study, we identified no direct causal impact in a European population between DVT and the COVID-19 susceptibility, severity, or hospitalisation

Biology · Confidence interval · Deep vein · Observational study · Odds ratio · Pleiotropy · Publication bias · Thrombosis · COVID-19 Clinical Research Studies · Dermatological and COVID-19 studies · Genetic Associations and Epidemiology · Medicine · Genetics · Internal Medicine

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