The Universal Vital Assessment (UVA) score at 6 hours post-resuscitation predicts mortality in hospitalized adults with severe sepsis in Mbarara, Uganda
Bibliographic Data
| ID | 19590941 |
|---|---|
| Authors | Megan Null (0009-0001-9584-4606, University of Virginia), Mark R Conaway (0000-0002-0459-2336, University of Virginia), Mark Conaway, Riley Hazard (0000-0003-3774-2705, The University of Melbourne), Louisa Edwards (0000-0001-9371-2805, University of Virginia), Kabanda Taseera (0000-0003-1397-9572, Mbarara University of Science and Technology), Rose Muhindo (0000-0001-7128-4870, Mbarara University of Science and Technology), Sam Olum (0000-0001-8918-0615, Gulu University), Amir Abdallah Mbonde (0000-0001-8241-0262, Mbarara University of Science and Technology), Christopher C Moore (0000-0001-6027-1732, Mbarara University of Science and Technology) |
| Editors | Mustafa A Barbhuiya |
| Year | 2024 |
| Volume | 4 |
| Issue | 10 |
| Pages | e0003797 |
| Publication date | 2024-10-22 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0003797 |
| PMID | 39436893 |
| OpenAlex | W4403635755 |
| Language | EN |
| Citations received | 1 |
| References cited | 24 |
Sepsis is the leading cause of global death with the highest burden found in sub-Saharan Africa (sSA). The Universal Vital Assessment (UVA) score is a validated resource-appropriate clinical tool to identify hospitalized patients in sSA who are at risk of in-hospital mortality. Whether a decrease in the UVA score over 6 hours of resuscitation from sepsis is associated with improved outcomes is unknown. We aimed to determine (1) the association between 6-hour UVA score and in-hospital mortality, and (2) if a decrease in UVA score from admission to 6 hours was associated with improved in-hospital mortality. We analyzed data from participants with severe sepsis aged ≥14 years enrolled at the Mbarara Regional Referral Hospital in Uganda from October 2014 through May 2015. Among 197 participants, the median (interquartile range) age was 34 (27–47) years, 99 (50%) were female and 116 (59%) were living with HIV. At 6 hours, of the 65 participants in the high-risk group, 28 (43%) died compared to 28 (30%) of 94 in the medium-risk group (odds ratio [OR] 0.56, 95% confidence interval [CI] 0.29,1.08, p = 0.086) and 3 (9%) of 33 in the low-risk group (OR 0.13, 95% CI 0.03, 0.42, p = 0.002). In a univariate analysis of the 85 participants who improved their UVA risk group at 6 hours, 20 (23%) died compared to 39 (36%) of 107 participants who did not improve (OR 0.54, 95% CI 0.27–1.06, p = 0.055). In the multivariable analysis, the UVA score at 6 hours (adjusted OR [aOR] 1.26, 95%CI 1.10–1.45, p
Confidence interval · Interquartile range · Multivariate analysis · Odds ratio · Referral · Resuscitation · Sepsis · Univariate analysis · Climate Change and Health Impacts · Disaster Response and Management · Medicine · Sepsis Diagnosis and Treatment · Emergency Medicine · Internal Medicine
| Citations per year | 1 |
|---|---|
| Citation span | 2025 - 2025 (1) |
| Highly cited | No |