Eclampsia among adolescent mothers in low- and middle-Income countries

Dados Bibliográficos

ID19592353
AutoresLaura van der Krogt (0009-0004-2040-0375, St Thomas' Hospital, autor correspondente), Alexandra Ridout (0000-0003-0988-7229, St Thomas' Hospital, autor correspondente), Nicola Vousden (0000-0001-5216-8268, University of Oxford, autor correspondente), Hannah L Nathan (0000-0002-4708-8973, St Thomas' Hospital, autor correspondente), Paul T Seed (0000-0001-7904-7933, St Thomas' Hospital, autor correspondente), Betty Sam Midwife (Sierra Leone Urban Research Centre, autor correspondente), Mariama Momoh Midwife (autor correspondente), Tom Sesay (autor correspondente), Francis Smart (0000-0002-9389-4730, autor correspondente), Mrutunjaya Bellad (Jawaharlal Nehru Medical College, autor correspondente), Bellington Vwalika (0000-0001-5548-8187, University of Zambia, autor correspondente), Andrew Shennan (0000-0001-5273-3132, St Thomas' Hospital, autor correspondente)
EditoresBethany Hedt-Gauthier Bethany Hedt-Gauthier
Ano2025
Volume5
Fascículo3
Páginase0003890
Data de publicação2025-03-26
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoPLOS Global Public Health (JOURNAL)
Identificadores do periódicoISSN: 2767-3375 • E-ISSN: 2767-3375
EditoraPublic Library of Science (PLoS) (PUBLISHER)
DOI10.1371/journal.pgph.0003890
PMID40138612
OpenAlexW4408864443
IdiomaEN
Citações recebidas1
Referências citadas25

Everyday, approximately 800 pregnant women die from preventable causes, with 95% of these deaths occurring in low- and middle-income countries. Adolescent mothers are disproportionally affected. Hypertensive disorders, including eclampsia, contribute to around 20% of direct maternal deaths, many of which are preventable with simple, cost-effective interventions. This study aims to quantify the risk of eclampsia among adolescent mothers in low- and middle-income countries. This secondary analysis used data from three large multi-center studies within the CRADLE programme of work, conducted across ten regions in Sub-Saharan Africa, India, and Haiti. Data on eclampsia and maternal age were prospectively collected from routine sources and active case finding. The incidence rates of eclampsia were calculated, and the relative risk of eclampsia in adolescents were calculated and compared to non-adolescent mothers. Among 601,343 deliveries, 3,098 cases of eclampsia were recorded (0·51%). The incidence of eclampsia varied widely, from 22 per 10,000 deliveries in Zambia to 142 per 10,000 deliveries in Sierra Leone, a 6·5-fold variation. Adolescents accounted for 34% of eclampsia cases (1065/3098). The relative risk of eclampsia in adolescents compared to older mothers ranged from 1·50 (95% CI 1.32 to 1.83) to 3·45 (95% CI 2.71 to 4.41) across sites (p

Confidence interval · Developing country · Eclampsia · Environmental health · Low and middle income countries · Obstetrics · Pregnancy · Psychiatry · Psychological intervention · Relative risk · Sierra leone · Socioeconomics · Birth, Development, and Health · Demography · Global Maternal and Child Health · Medicine · Pregnancy and preeclampsia studies