Association between triglyceride-glucose index and estimated 10-year risk of cardiovascular disease in Nigerian non-diabetic hypertensives
A cross-sectional study
Bibliographic Data
| ID | 19593312 |
|---|---|
| Authors | Casmir Amadi (0000-0001-7364-9079, University of Lagos, corresponding author), Ugochi Chinenye Okorafor (0009-0002-1928-0105, King's College Hospital, corresponding author), Chiamaka I Okorafor (0009-0002-1755-7895, Lagos State Health Service Commission, corresponding author), Micah N Okwah (0009-0004-6023-1756, Lagos University Teaching Hospital, corresponding author), Precious O Akanbi (Lagos University Teaching Hospital, corresponding author), Onyinyechi Victoria Okam (0000-0002-2253-0200, Babcock University, corresponding author), Christie I Udenze (University of Lagos, corresponding author), Amam Mbakwem (0000-0003-3395-9042, University of Lagos, corresponding author), Amam C Mbakwem, Jayne N Ajuluchukwu (University of Lagos, corresponding author) |
| Editors | Ransome Eke |
| Year | 2025 |
| Volume | 5 |
| Issue | 7 |
| Pages | e0004760 |
| Publication date | 2025-07-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0004760 |
| PMID | 40591635 |
| OpenAlex | W4411866778 |
| Language | EN |
| References cited | 36 |
The Triglyceride Glucose (TyG) index is a new and sensitive marker of Insulin Resistance (IR). Its relationship with a 10-year cardiovascular risk (CVD) in hypertensives in Nigeria is currently unknown. This was a cross-sectional study involving 1,430 adult Nigerians with hypertension. The TyG index of subjects was divided into quartiles (Q1-Q4), and its association with 10-year CVD risk using Framingham 10-year Cardiovascular Risk Score was explored. The mean age of the study population was 55.8 ± 13.9 years with a male preponderance of 54.1%. The mean TyG index was 8.72 ± 0.6 with a significantly higher value in males (8.77 ± 0.6 vs 8.67 ± 0.5; p = 0.001). This trend was consistent across all age groups. The prevalence of elevated TyG index was 51.9% and 44.7% in males and females respectively. Using ROC the cut-offs that predicted moderate to high CVD risk were 8.85 (0.69(0.57-0.80; 95% CI; p = 0.001) and 8.74 (0.688 (0.59-0.78; 95% CI; p = 0.001) for males and females respectively. After adjustment for well-known risk factors, an elevated TyG index was associated with an increased 10-year CVD risk in females only. The TyG index is associated with an increased 10-year cardiovascular risk especially in females and a value of at least 8.7 is reasonably accurate to predict a 10-year CVD risk in Nigerians with hypertension
Cholesterol · Confidence interval · Cross-sectional study · Diabetes mellitus · Disease · Environmental health · Framingham Risk Score · Nigerians · Population · Quartile · Risk factor · Triglyceride · Blood Pressure and Hypertension Studies · Diabetes, Cardiovascular Risks, and Lipoproteins · Liver Disease Diagnosis and Treatment · Medicine · Endocrinology · Internal Medicine
| Highly cited | No |
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