Gynecologic infection rates after ablation treatment for cervical intraepithelial neoplasia grade 2 and higher (CIN2+)
Secondary analysis of a non-inferiority randomized trial
Bibliographic Data
| ID | 19593767 |
|---|---|
| Authors | Rachel Masch (0000-0002-3761-858X, Mount Sinai Hospital, corresponding author), Gabriel Conzuelo-Rodriguez (0000-0002-4464-6095, corresponding author), Jameson A Mitchell (0000-0003-3256-1702, Cleveland Clinic Lerner College of Medicine, corresponding author), Karla Alfaro (0000-0002-7597-5748, corresponding author), M Soler (0000-0002-1193-8710, Cleveland Clinic, corresponding author), Luis F Chavez (corresponding author), Suhui Wu (0000-0003-1674-4111, Shanxi Medical University, corresponding author), Jinfen Sun, Sun Jinfen (Shanxi Medical University, corresponding author), Longhua Hu (0000-0001-8478-0654, Shanxi Medical University, corresponding author), Dayana Marinela-Hernandez (corresponding author), Todd A Alonzo (0000-0002-6772-6581, University of Southern California, corresponding author), Juan C Felix (0000-0001-7663-1050, Medical College of Wisconsin, corresponding author), Miriam Cremer (0000-0002-5163-8739, Cleveland Clinic, corresponding author), Miriam L Cremer |
| Editors | Julia Robinson (0000-0003-0719-3995) |
| Year | 2024 |
| Volume | 4 |
| Issue | 7 |
| Pages | e0003333 |
| Publication date | 2024-07-10 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0003333 |
| PMID | 38985817 |
| OpenAlex | W4400488099 |
| Language | EN |
| References cited | 11 |
Although concerns have been raised regarding potential infection and morbidity in women undergoing ablation treatment for cervical precancer in low- and middle-income countries (LMIC), there is extremely limited data to substantiate this claim. This is a secondary analysis of a randomized non-inferiority trial (id: NCT03084081) that compares the efficacy and safety of three ablation treatments for biopsy-confirmed cervical intraepithelial neoplasia grade 2 or higher (CIN2+): CO 2 gas-based cryotherapy, non-gas cryotherapy, and thermal ablation (TA). Here, we present findings regarding the incidence of sexually transmitted infections (STI) and vaginitis post-treatment. Samples were collected at enrollment and again at 6 weeks post-treatment and assessed for STIs ( Chlamydia trachomatis (CT), Neisseria gonorrhea (NG), and Trichomonas vaginalis (TV)) and vaginitis (Bacterial vaginosis (BV) and/or Candida albicans (Candida)). This analysis reflects 864 women with baseline and 6-week follow-up data. None of the ablative treatments put women at increased risk for STIs (CT, NG, TV) or vaginitis (BV, Candida). While most women adhered to post-treatment recommendations (97%) and no difference by treatment arm was observed, the incidence of STIs at follow-up in women that did not adhere with a given recommendation was higher compared to their adherent counterparts. The incidence of gynecologic infection did not increase with any of the ablation treatments from baseline to the six-week follow-up. Non-gas cryotherapy and TA emerge as safe alternatives to gas-based cryotherapy with respect to gynecologic infection rates
Cancer · Cervical cancer · Cervical intraepithelial neoplasia · Colposcopy · Gynecology · Obstetrics · Randomized controlled trial · Cervical Cancer and HPV Research · Endometrial and Cervical Cancer Treatments · Medicine · Ovarian cancer diagnosis and treatment · Internal Medicine · Oncology
| Highly cited | No |
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