Effect of cassava ( Manihot esculenta crentz ) on thyroid status under conditions of varying iodine intake in rats
Bibliographic Data
| ID | 20346235 |
|---|---|
| Authors | Amar K Chandra (0000-0002-1231-2074, University of Calcutta, corresponding author), Dishari Ghosh (0000-0002-1300-6538, University of Calcutta), Sanjukta Mukhopadhyay (University of Calcutta), Smritiratan Tripathy (University of Calcutta) |
| Year | 2006 |
| Volume | 3 |
| Issue | 3 |
| Publication date | 2006-10-04 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v3i3.31170 |
| OpenAlex | W2084027171 |
| Language | EN |
| Citations received | 1 |
| References cited | 1 |
Cassava (Manihot esculenta Crantz), a widely used common vegetable of Indian origin contains dietary goitrogens. Goitrogenic content, in vitro anti-thyroidal activity and in vivo antithyroid potential of fresh and cooked cassava of Indian origin in albino rats with and without iodine supplementation were evaluated in this study. In vitro inhibition of thyroid peroxidase (TPO )activity was found with fresh and cooked cassava extract but the presence of extra iodide in the incubation media had shown reduction in such inhibition to an extent. Inhibition constant (IC50) and PTU equivalence of fresh cassava were 42.5 ± 1.35μg and 2.21 respectively. After consumption, cyanogenic constituents in cassava are metabolized to thiocyanate and iodine-retaining capacity seems to be dependent on thiocyanate exposure. In cassava fed rats, the urinary iodine concentration resembled the state of adequate iodine nutriture but thyroid gland fails to utilize available iodine. Increased thyroid weight (P < 0.001), inhibited thyroid peroxidase (TPO) activity and reduced thyroid hormone profiles (P < 0.001) were noted in fresh and cooked cassava fed rats, resembling a relative state of morphological as well as biochemical hypothyroidism even in presence of adequate iodine. African Journal of Traditional, Complementary and Alternative Medicines Vol. 3(3) 2006: 87-99
Biology · Botany · Hormone · In vitro · In vivo · Incubation · Iodide · Iodine · Manihot esculenta · Thyroid · Thyroid peroxidase · Cassava research and cyanide · Chemistry · Medicine · Vitamin K Research Studies · Biochemistry · Biotechnology · Endocrinology · Food Science · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 0.17 |
| Citation span | 2020 - 2020 (1) |
| Citation velocity | historical |
| Highly cited | No |