Study On The Anti-Depressant Effect Of Chaihu Guizhi Decoction And Its Mechinisims Of Actions
Bibliographic Data
| ID | 20346333 |
|---|---|
| Authors | Yang Liu (0000-0003-1220-7044, Peking University), Chao Cao (0000-0002-0455-1171, Tsinghua University), Hui Ding (0000-0002-8694-5456) |
| Year | 2014 |
| Volume | 11 |
| Issue | 2 |
| Pages | 273 |
| Publication date | 2014-07-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v11i2.7 |
| PMID | 25435607 |
| OpenAlex | W2066650480 |
| Language | EN |
| Citations received | 1 |
| References cited | 2 |
BACKGROUND: Chaihu Guizhi has the effects of treating exogenous wind-cold; alternating episodes of chills and fever; noisy nose and retching; strong headache; chest and rib-side pain, and fullness, in clinical practice, it can also be used for the treatment of depression. The objective of this paper was to study the anti-depressant effect of Chaihu Guizhi decoction and its mechanism. MATERIALS AND METHODS: The anti-depressant effect of Chaihu Guizhi decoction was investigated by forced swimming test, tail suspension test and antagonism of reserpine hypothermia test in mice. RESULTS: Chaihu Guizhi decoction could significantly shorten immobility time of mice in the forced swimming test, and dose-dependence significantly shorten immobility time of mice in the tail suspension test, after administration of 50, 100, and 200mg/kg, Chaihu Guizhi decoction, a significant dose-dependent antagonism of reserpine-induced hypothermia was observed in mice of each treatment group. CONCLUSION: Chaihu Guizhi decoction has an antidepressant effect
Anesthesia · Antidepressant · Behavioural despair test · Decoction · Depressant · Hypothermia · Reserpine · Tail suspension test · Traditional medicine · Medicine · Traditional Chinese Medicine Studies · Tryptophan and brain disorders · Ziziphus Jujuba Studies and Applications · Internal Medicine · Pharmacology
| Citations per year | 0.13 |
|---|---|
| Citation span | 2018 - 2018 (1) |
| Highly cited | No |